Chemical Name: (±)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide hemifumarate
Biological ActivityClass III antiarrhythmic. Blocks the rapid component of delayed rectifier K+ current (IKr); also blocks hERG channels and L-type Ca2+ channels. Shown to activate a slow inward Na+ current in guinea pig ventricular cells. Used to terminate atrial fibrillation and atrial flutter; can prolong QT.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Structural determinants of HERG channel block by clofilium and ibut.
Perry et al.
Ionic mechanism of ibut. in human atrium: evidence for a drug-induced Na+ current through nifed. inhibited inward channel.
Lee and Lee
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