Chemical Name: (±)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide hemifumarate
Biological ActivityClass III antiarrhythmic. Blocks the rapid component of delayed rectifier K+ current (IKr); also blocks hERG channels and L-type Ca2+ channels. Shown to activate a slow inward Na+ current in guinea pig ventricular cells. Used to terminate atrial fibrillation and atrial flutter; can prolong QT.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Structural determinants of HERG channel block by clofilium and ibutilide.
Perry et al.
Ionic mechanism of ibutilide in human atrium: evidence for a drug-induced Na+ current through nifedipine inhibited inward channel.
Lee and Lee
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