Chemical Name: (±)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide hemifumarate
Biological Activity Class III antiarrhythmic. Blocks the rapid component of delayed rectifier K+ current (IKr); also blocks hERG channels and L-type Ca2+ channels. Shown to activate a slow inward Na+ current in guinea pig ventricular cells. Used to terminate atrial fibrillation and atrial flutter; can prolong QT.
Soluble to 100 mM in DMSO and to 100 mM in water
Store at RT
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Kishimoto T et al.
Leucocyte Typing VI. Garland Publishing Inc. London.
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