IC 87201

Catalog # Availability Size / Price Qty
IC 87201 | CAS No. 866927-10-8 | Additional NMDA Receptor Compounds
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Description: nNOS-PSD95 protein-protein interaction inhibitor; also antinociceptive and antidepressant

Chemical Name: 2-[(1H-Benzotriazol-6-ylamino)methyl]-4,6-dichlorophenol

Purity: ≥99%

Product Details
Citations (1)

Biological Activity

IC 87201 is an inhibits binding of the NMDA receptor postsynaptic density protein 95 kDa (PSD95) to nNOS (EC50 = 23.94 μM), while not affecting the PSD95-ErbB4 interaction. Inhibits glutamate-induced cell death in cultured cortical neurons. Exhibits antinociceptive effects in inflammatory pain models in vivo. Also exhibits antidepressant-like activitiy in animal models.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for IC 87201

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