Chemical Name: 4-Chloro-N-(6-chloro-3-pyridinyl)benzamide
Biological ActivityICA 110381 is a KV7.2/7.3 activator (EC50 = 0.38 μM). Decreases neuronal excitability in CA1 hippocampal neurons. Exhibits anticonvulsive properties in amygdala-kindled rats, a model for complex partial seizures.
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Complete Your Research
N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy.
Amato et al.
ACS Med.Chem.Lett., 2011;2:481
The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential.
Boehlen et al.
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