Inhibitor of TCF/β
-catenin-mediated transcription. Selectively inhibits β
-catenin/CBP interaction; displays no effect on β
-catenin/p300 interaction. Exhibits growth inhibitory effects in colon carcinoma cell lines (SW480 and HCT-116 cells); also displays efficacy in Min mouse and nude mouse SW620 xenograft models.
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All Tocris products are intended for laboratory research use only.
A small molecule inhibitor of β-catenin/CREB-binding protein transcription.
Emami et al.
Targeting wnt signaling in colon cancer stem cells.
De Sousa et al.
Clin.Cancer Res., 2011;17:647
Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-respo
Zhou et al.
The citations listed below are publications that use Tocris products. Selected citations for ICG 001 include:
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