ICG 001

  ( 5 citations )    
Product Datasheet
Catalog Number:4505
Chemical Name:(6S,9aS)-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
Product Details
Citations (5)
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Reviews
Biological Activity
Inhibitor of TCF/β-catenin-mediated transcription. Selectively inhibits β-catenin/CBP interaction; displays no effect on β-catenin/p300 interaction. Exhibits growth inhibitory effects in colon carcinoma cell lines (SW480 and HCT-116 cells); also displays efficacy in Min mouse and nude mouse SW620 xenograft models.
Technical Data
  • M.Wt:
    548.63
  • Formula:
    C33H32N4O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    847591-62-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for ICG 001 include:

5 Citations: Showing 1 - 5
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  1. β-Catenin Directs Nuclear Factor-κB p65 Output via CREB-Binding Protein/p300 in Human Airway Smooth Muscle.
    Authors: Koopmans Et al.
    Front Immunol  2017;8:1086
  2. Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin.
    Authors: Long Et al.
    J Clin Invest  2016;7:10354
  3. WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited.
    Authors: Boulter Et al.
    PLoS One  2015;125:1269
  4. Non-Canonical Wnt Predominates in Activated Rat Hepatic Stellate Cells, Influencing HSC Survival and Paracrine Stimulation of Kupffer Cells.
    Authors: Corbett Et al.
    J Immunol  2015;10:e0142794
  5. A zebrafish chemical suppressor screening identifies small molecule inhibitors of the Wnt/β-catenin pathway.
    Authors: Nishiya Et al.
    Chem Biol  2014;21:530

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