Catalog Number: 4505
Chemical Name: (6S,9aS)-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
Biological Activity
Inhibitor of TCF/β-catenin-mediated transcription. Selectively inhibits β-catenin/CBP interaction; displays no effect on β-catenin/p300 interaction. Exhibits growth inhibitory effects in colon carcinoma cell lines (SW480 and HCT-116 cells); also displays efficacy in Min mouse and nude mouse SW620 xenograft models.
Technical Data
  • M.Wt:
    548.63
  • Formula:
    C33H32N4O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    847591-62-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A small molecule inhibitor of β-catenin/CREB-binding protein transcription.
    Emami et al.
    Proc.Natl.Acad.Sci.USA, 2004;101:12682
  2. Targeting wnt signaling in colon cancer stem cells.
    De Sousa et al.
    Clin.Cancer Res., 2011;17:647
  3. Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-respo
    Zhou et al.
    J.Biol.Chem., 2012;287:7026
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ICG 001 include:

3 Citations: Showing 1 - 3
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  1. Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin.
    Authors: Long Et al.
    J Clin Invest 2016;7:10354
  2. WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited.
    Authors: Boulter Et al.
    PLoS One 2015;125:1269
  3. Non-Canonical Wnt Predominates in Activated Rat Hepatic Stellate Cells, Influencing HSC Survival and Paracrine Stimulation of Kupffer Cells.
    Authors: Corbett Et al.
    J Immunol 2015;10:e0142794

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