Chemical Name: (6S,9aS)-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
Biological ActivityInhibitor of TCF/β-catenin-mediated transcription. Selectively inhibits β-catenin/CBP interaction; displays no effect on β-catenin/p300 interaction. Exhibits growth inhibitory effects in colon carcinoma cell lines (SW480 and HCT-116 cells); also displays efficacy in Min mouse and nude mouse SW620 xenograft models.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A small molecule inhibitor of β-catenin/CREB-binding protein transcription.
Emami et al.
Targeting wnt signaling in colon cancer stem cells.
De Sousa et al.
Clin.Cancer Res., 2011;17:647
Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-respo
Zhou et al.
Citations for ICG 001
The citations listed below are publications that use Tocris products. Selected citations for ICG 001 include:
12 Citations: Showing 1 - 10
Temporal Regulation of Natural Killer T Cell Interferon Gamma Responses by β-Catenin-Dependent and -Independent Wnt Signaling.
Authors: Kling Et al.
Front Immunol 2018;9:483
Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis.
Cell Discov 2018;4:21
Effect of inhibition of CBP-coactivated β-catenin-mediated Wnt signalling in uremic rats with vascular calcifications.
PLoS One 2018;13(8):e0201936
Titanium particle-induced osteogenic inhibition and bone destruction are mediated by the GSK-3β/β-catenin signal pathway.
Authors: Gu Et al.
Cell Death Dis 2017;8:e2878
β-Catenin Directs Nuclear Factor-κB p65 Output via CREB-Binding Protein/p300 in Human Airway Smooth Muscle.
Authors: Koopmans Et al.
Front Immunol 2017;8:1086
ICG-001 affects DRP1 activity and ER stress correlative with its anti-proliferative effect.
Authors: Zinecker Et al.
Sam68 Allows Selective Targeting of Human Cancer Stem Cells.
Authors: Benoit Et al.
Cell Chem Biol 2017;24:833
Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin.
Authors: Long Et al.
J Clin Invest 2016;7:10354
Selective targeting of CREB-binding protein/β-catenin inhibits growth of and extracellular matrix remodelling by airway smooth muscle.
Authors: Koopmans Et al.
Br J Pharmacol 2016;173:3327
WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited.
Authors: Boulter Et al.
PLoS One 2015;125:1269
Non-Canonical Wnt Predominates in Activated Rat Hepatic Stellate Cells, Influencing HSC Survival and Paracrine Stimulation of Kupffer Cells.
Authors: Corbett Et al.
J Immunol 2015;10:e0142794
A zebrafish chemical suppressor screening identifies small molecule inhibitors of the Wnt/β-catenin pathway.
Authors: Nishiya Et al.
Chem Biol 2014;21:530
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for ICG 001
Average Rating: 5 (Based on 1 Review)
Have you used ICG 001?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
BLaER1 DRP1 KO cell lines C12 and F11 and a corresponding wt-control cell line were treated with 10 µM ICG-001 or vehicle control for 2.5 h.