ICG 001

Catalog # Availability Size / Price Qty
4505/10
4505/50
ICG 001 | CAS No. 780757-88-2 | beta-Catenin Inhibitors
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Description: Inhibits TCF/β-catenin-mediated transcription

Chemical Name: (6S,9aS)-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide

Purity: ≥98%

Product Details
Citations (12)
Supplemental Products
Reviews

Biological Activity

Inhibitor of TCF/β-catenin-mediated transcription. Selectively inhibits β-catenin/CBP interaction; displays no effect on β-catenin/p300 interaction. Exhibits growth inhibitory effects in colon carcinoma cell lines (SW480 and HCT-116 cells); also displays efficacy in Min mouse and nude mouse SW620 xenograft models.

Technical Data

M.Wt:
548.63
Formula:
C33H32N4O4
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
780757-88-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for ICG 001

The citations listed below are publications that use Tocris products. Selected citations for ICG 001 include:

12 Citations: Showing 1 - 10

  1. Temporal Regulation of Natural Killer T Cell Interferon Gamma Responses by β-Catenin-Dependent and -Independent Wnt Signaling.
    Authors: Kling Et al.
    Front Immunol  2018;9:483
  2. Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis.
    Authors: Rothberg
    Cell Discov  2018;4:21
  3. Effect of inhibition of CBP-coactivated β-catenin-mediated Wnt signalling in uremic rats with vascular calcifications.
    Authors: Gravesen
    PLoS One  2018;13(8):e0201936
  4. Titanium particle-induced osteogenic inhibition and bone destruction are mediated by the GSK-3β/β-catenin signal pathway.
    Authors: Gu Et al.
    Cell Death Dis  2017;8:e2878
  5. β-Catenin Directs Nuclear Factor-κB p65 Output via CREB-Binding Protein/p300 in Human Airway Smooth Muscle.
    Authors: Koopmans Et al.
    Front Immunol  2017;8:1086
  6. ICG-001 affects DRP1 activity and ER stress correlative with its anti-proliferative effect.
    Authors: Zinecker Et al.
    Oncotarget  2017;8:106764
  7. Sam68 Allows Selective Targeting of Human Cancer Stem Cells.
    Authors: Benoit Et al.
    Cell Chem Biol  2017;24:833
  8. Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin.
    Authors: Long Et al.
    J Clin Invest  2016;7:10354
  9. Selective targeting of CREB-binding protein/β-catenin inhibits growth of and extracellular matrix remodelling by airway smooth muscle.
    Authors: Koopmans Et al.
    Br J Pharmacol  2016;173:3327
  10. WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited.
    Authors: Boulter Et al.
    PLoS One  2015;125:1269

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