ICI 63197

Key Product Details

Product Description

Potent phosphodiesterase (PDE) 4 inhibitor (IC₅₀ = 35 nM for inhibition of [³H]-rolipram binding to rat brain). Antidepressant following systemic administration in vivo.

Product Specifications for ICI 63197

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ICI 63197

The following data is based on the product molecular weight 207.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.83 mL	24.13 mL	48.26 mL
5 mM	0.97 mL	4.83 mL	9.65 mL
10 mM	0.48 mL	2.41 mL	4.83 mL
50 mM	0.10 mL	0.48 mL	0.97 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wachtel Potential antidepressant activity of rolipram and other selective cyclic adenosine 3',5'-monophosphate phosphodiesterase inhibitors. Neuropharmacology 1983 PMID: 6302550
• Zhao Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [³H]piclamilast and [³H]rolipram J.Pharmacol.Exp.Ther. 2003 PMID: 12704225
• Kaulen Autoradiographic mapping of a selective cyclic adenosine monophosphate phosphodiesterase in rat brain with the antidepressant [³H]rolipram. Brain Res. 1989 PMID: 2557965

Product Documents for ICI 63197