Potent phosphodiesterase (PDE) 4 inhibitor (IC50
= 35 nM for inhibition of [3
H]-rolipram binding to rat brain). Antidepressant following systemic administration in vivo
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All Tocris products are intended for laboratory research use only.
Autoradiographic mapping of a selective cyclic adenosine monophosphate phosphodiesterase in rat brain with the antidepressant [3H]rolipram.
Kaulen et al.
Brain Res., 1989;503:229
Potential antidepressant activity of rolipram and other selective cyclic adenosine 3',5'-monophosphate phosphodiesterase inhibitors.
Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram
Zhao et al.