Potent inhibitor of β
-catenin-responsive transcription (CRT) (IC50
= 40.3 nM in assays of Wnt pathway activity). Thought to directly influence the interaction between β
-catenin and TCF4. Induces marked G0
cell cycle arrest in HCT-116 and HT29 cell lines.
Soluble to 75 mM in DMSO
Store at +4°C
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All Tocris products are intended for laboratory research use only.
An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway.
Gonsalves et al.
The citations listed below are publications that use Tocris products. Selected citations for iCRT 14 include:
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