iCRT 14

Catalog # Availability Size / Price Qty
4299/10
4299/50
iCRT 14 | CAS No. 677331-12-3 | beta-Catenin Compounds
1 Image
Description: Inhibits β-catenin-responsive transcription (CRT)

Chemical Name: 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedion

Purity: ≥99%

Product Details
Citations (9)
Supplemental Products
Reviews

Biological Activity

iCRT 14 is a potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Thought to directly influence the interaction between β-catenin and TCF4. Induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines. Also acts as transfection enhancer; enhances transgene expression in PC-3 cells by 16 to 35-fold using nonviral systems.

Technical Data

M.Wt:
375.44
Formula:
C21H17N3O2S
Solubility:
Soluble to 75 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
677331-12-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Enhancement of transgene expression by the β-catenin inhibitor iCRT14.
    Spivack et al.
    Plasmid, 2021;

Product Datasheets

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Citations for iCRT 14

The citations listed below are publications that use Tocris products. Selected citations for iCRT 14 include:

9 Citations: Showing 1 - 9

  1. Pro-inflammatory role of Wnt/β-catenin signaling in endothelial dysfunction.
    Authors: Sarah J Et al.
    Front Cardiovasc Med  2023;9:1059124
  2. Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids.
    Authors: Ling Et al.
    Cell Stem Cell  2021;28:1090-1104.e6
  3. Heparanase-Induced Activation of AKT Stabilizes β-Catenin and Modulates Wnt/β-Catenin Signaling during Herpes Simplex Virus 1 Infection.
    Authors: Alex M Et al.
    MBio  2021;12:e0279221
  4. Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation.
    Authors: Paula Et al.
    Dev Cell  2020;53:545-560.e7
  5. Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells.
    Authors: Brown Et al.
    Aging Cell  2019;18:e12844
  6. Trypanosoma cruzi Exploits Wnt Signaling Pathway to Promote Its Intracellular Replication in Macrophages.
    Authors: Volpini Et al.
    Front Immunol  2018;9:859
  7. Mutant Isocitrate Dehydrogenase 1 Disrupts PKM2-β-Catenin-BRG1 Transcriptional Network-Driven CD47 Expression.
    Authors: Gowda Et al.
    Mol Cell Biol  2018;38
  8. Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription.
    Authors: Kennedy Et al.
    Proc Natl Acad Sci U S A  2016;113:3545
  9. Differential modulation of the oligodendrocyte transcriptome by sonic hedgehog and bone morphogenetic protein 4 via opposing effects on histone acetylation.
    Authors: Wu Et al.
    J Neurosci  2012;32:6651

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