iCRT 14

Catalog # Availability Size / Price Qty
4299/10
4299/50
iCRT 14 | CAS No. 677331-12-3 | beta-Catenin Compounds
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Description: Inhibits β-catenin-responsive transcription (CRT)

Chemical Name: 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedion

Purity: ≥99%

Product Details
Citations (5)
Supplemental Products
Reviews (1)

Biological Activity

Potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Thought to directly influence the interaction between β-catenin and TCF4. Induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines. Also acts as transfection enhancer; enhances transgene expression in PC-3 cells by 16 to 35-fold using nonviral systems.

Technical Data

M.Wt:
375.44
Formula:
C21H17N3O2S
Solubility:
Soluble to 75 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
677331-12-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway.
    Gonsalves et al.
    Proc.Natl.Acad.Sci.USA, 2011;108:5954
  2. Winning WNT: race to Wnt signaling inhibitors.
    Watanabe and Dai
    Proc.Natl.Acad.Sci.USA, 2011;108:5929
  3. Enhancement of transgene expression by the β-catenin inhibitor iCRT14.
    Spivack et al.
    Plasmid, 2021;

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Citations for iCRT 14

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Useful Wnt inhibitor
By Anonymous on 07/11/2020
Application: Species: Human

HCT116 cells were treated with different concentrations of iCRT-14 for 24 hours and the cells were used for transwell assays to investigate the effects of Wnt inhibitor on cell migration.


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