iCRT 14

  ( 2 citations )    
Product Datasheet
Catalog Number:4299
Chemical Name:5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedion
Product Details
Citations (2)
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Reviews
Biological Activity
Potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Thought to directly influence the interaction between β-catenin and TCF4. Induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines.
Technical Data
  • M.Wt:
    375.44
  • Formula:
    C21H17N3O2S
  • Solubility:
    Soluble to 75 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    677331-12-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for iCRT 14 include:

2 Citations: Showing 1 - 2
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  1. Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription.
    Authors: Kennedy Et al.
    Proc Natl Acad Sci U S A  2016;113:3545
  2. Differential modulation of the oligodendrocyte transcriptome by sonic hedgehog and bone morphogenetic protein 4 via opposing effects on histone acetylation.
    Authors: Wu Et al.
    J Neurosci  2012;32:6651

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