Chemical Name: 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedion
Biological ActivityPotent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Thought to directly influence the interaction between β-catenin and TCF4. Induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway.
Gonsalves et al.
Winning WNT: race to Wnt signaling inhibitors.
Watanabe and Dai
Citations for iCRT 14
The citations listed below are publications that use Tocris products. Selected citations for iCRT 14 include:
5 Citations: Showing 1 - 5
Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells.
Authors: Brown Et al.
Aging Cell 2019;18:e12844
Trypanosoma cruzi Exploits Wnt Signaling Pathway to Promote Its Intracellular Replication in Macrophages.
Authors: Volpini Et al.
Front Immunol 2018;9:859
Mutant Isocitrate Dehydrogenase 1 Disrupts PKM2-β-Catenin-BRG1 Transcriptional Network-Driven CD47 Expression.
Authors: Gowda Et al.
Mol Cell Biol 2018;38
Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription.
Authors: Kennedy Et al.
Proc Natl Acad Sci U S A 2016;113:3545
Differential modulation of the oligodendrocyte transcriptome by sonic hedgehog and bone morphogenetic protein 4 via opposing effects on histone acetylation.
Authors: Wu Et al.
J Neurosci 2012;32:6651
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for iCRT 14
There are currently no reviews for this product. Be the first to review iCRT 14 and earn rewards!
Have you used iCRT 14?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image