Catalog Number: 0793
Alternate Names: RX 781094
Chemical Name: 2-(1,4-Benzodioxan-2-yl)-2-imidazoline hydrochloride
Biological Activity
α2-adrenoceptor antagonist, and I2 ligand, selective over I1 sites (pKi values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I1, I2, α2A, α2B, and α2C receptors respectively).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Evidence for two different imidazoline sites on pancreatic B cells and vascular bed in rat.
    Berdeu et al.
    Eur.J.Pharmacol., 1995;275:91
  2. 'Seeing through a glass darkly': casting light on imidazoline 'I' sites.
    Eglen et al.
    TiPS, 1998;19:381
  3. Idazoxan: a novel pharmacological tool for the study of α2-adrenoceptors.
    J.Pharmacol., 1986;17:113
  4. Keeping an eye on the I site: imidazoline-preferring receptors.
    Michel and Ernsberger
    TIPS, 1992;13:369

The citations listed below are publications that use Tocris products. Selected citations for Idazoxan hydrochloride include:

2 Citations: Showing 1 - 2
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  1. μ-Opioid receptor activation and noradrenaline transport inhibition by tapentadol in rat single locus coeruleus neurons.
    Authors: Sadeghi Et al.
    Development 2015;172:460
  2. Medullary norepinephrine neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis.
    Authors: Bucher Et al.
    J Cereb Blood Flow Metab 2014;34:1128

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