Idazoxan hydrochloride

Key Product Details

Product Description

Idazoxan hydrochloride is a α₂-adrenoceptor antagonist, and I₂ ligand, selective over I₁ sites (pK_i values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I₁, I₂, α_2A, α_2B, and α_2C receptors respectively).

Product Specifications for Idazoxan hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Idazoxan hydrochloride

The following data is based on the product molecular weight 240.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

5 4 3 2 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.15 mL	20.77 mL	41.55 mL
5 mM	0.83 mL	4.15 mL	8.31 mL
10 mM	0.42 mL	2.08 mL	4.15 mL
50 mM	0.08 mL	0.42 mL	0.83 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Michel and Ernsberger Keeping an eye on the I site: imidazoline-preferring receptors. TIPS 1992 PMID: 1413085
• Dabir Idazoxan: a novel pharmacological tool for the study of α₂-adrenoceptors. J.Pharmacol. 1986 PMID: 2875218
• Eglen 'Seeing through a glass darkly': casting light on imidazoline 'I' sites. TiPS 1998 PMID: 9786027
• Berdeu Evidence for two different imidazoline sites on pancreatic B cells and vascular bed in rat. Eur.J.Pharmacol. 1995 PMID: 7774667

Product Documents for Idazoxan hydrochloride