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(+)-Igmesine hydrochloride

Catalog #: 2332 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2332/10
2332/50
(+)-Igmesine hydrochloride | CAS No. 130152-35-1 | Sigma1 Receptor Ligands
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Description: Selective σ1 ligand; antidepressant

Chemical Name: (R)-(+)-N-Cyclopropylmethyl-α-ethyl-N-methyl-α-[(2E)-3-phenyl-2-propenyl)benzenemethanamine hydrochloride

Purity: ≥98%

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Biological Activity

(+)-Igmesine hydrochloride is a selective σ1 receptor ligand (KD = 19.1 nM), with little or no activity at σ2 receptors (IC50 > 1000 nM). Inhibits the NMDA-induced increase in cGMP in a concentration-dependent manner (IC50 value is approximately 100 nM). Weak inhibitor of brain 5-HT uptake in vitro. Exhibits neuroprotective and antidepressant effects.

Technical Data

M.Wt:
355.94
Formula:
C23H29N.HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
130152-35-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

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