Catalog Number: 5561
Chemical Name: (2-[3-[1-(6-[[7-[[4-Chloro-3-[[4-(2,5-dichlorobenzamido)phenyl]carbamoyl]phenyl]amino]-7-oxoheptylamino]-6-oxohexyl]-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1-propen-1-yl]-1-ethyl-3,3-dimethyl-5-sulfo-3H-indolium, inner salt
Biological Activity
Potent fluorescent Smo antagonist (IC50 = 100 nM). Non-fluorescent analog IHR 1 also available.
Technical Data
  • M.Wt:
    1174.64
  • Formula:
    C58H63Cl3N6O10S2
  • Solubility:
    Soluble to 5 mM in DMSO
  • Purity:
    >95%
  • Storage:
    Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation.
    Fan et al.
    Chem.Biol., 2014;21:1680
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