Catalog Number: 5554
Chemical Name: N,N'-1,4-Phenylenebis[2,5-dichlorobenzamide]
Biological Activity
Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro. Fluorescent analog IHR-Cy3 also available.
Technical Data
  • M.Wt:
    454.13
  • Formula:
    C20H12Cl4N2O2
  • Solubility:
    Soluble to 20 mM in DMSO with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    548779-60-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation.
    Fan et al.
    Chem.Biol., 2014;21:1680

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