Chemical Name: N,N'-1,4-Phenylenebis[2,5-dichlorobenzamide]
Biological ActivityIHR 1 is a potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.
Fluorescent Analog also available.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation.
Fan et al.
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VersaClone cDNA Plasmids
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