Chemical Name: N,N'-1,4-Phenylenebis[2,5-dichlorobenzamide]
Biological ActivityPotent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.
Fluorescent Analog also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation.
Fan et al.
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VersaClone cDNA Plasmids
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