IHR 1

Key Product Details

Product Description

IHR 1 is a potent Smo antagonist (IC₅₀ = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.

Fluorescent Analog also available.

Product Specifications for IHR 1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for IHR 1

The following data is based on the product molecular weight 454.13.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.01 mL	55.05 mL	110.10 mL
1 mM	2.20 mL	11.01 mL	22.02 mL
2 mM	1.10 mL	5.51 mL	11.01 mL
10 mM	0.22 mL	1.10 mL	2.20 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Fan The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem.Biol. 2014 PMID: 25484239

Product Documents for IHR 1