Iloprost

Catalog # Availability Size / Price Qty
2038/1
Iloprost | CAS No. 78919-13-8 | Prostanoid Receptor Agonists
1 Image
Description: Prostacyclin (PGI2) analog
Alternative Names: ZK 36374

Chemical Name: (5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-ynyl]-2(1H)-pentalenylidene]pentanoic acid

Purity: ≥97%

Product Details
Citations (2)
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Reviews

Biological Activity

Prostacyclin (PGI2) analog that binds with high affinity to IP, EP1 and EP3 receptors (Ki values are 11, 11, 56, 284, 619, 1035, 1870 and 6487 nM for IP, EP1, EP3, EP4, FP, DP, EP2 and TP receptors respectively). Inhibits platelet aggregation induced by collagen, thrombin and ADP (IC50 values are 0.24, 0.71 and 1.07 nM respectively).

Technical Data

M.Wt:
360.49
Formula:
C22H32O4
Solubility:
Soluble in methyl acetate (supplied pre-dissolved - 5mg/ml)
Purity:
≥97%
Storage:
Desiccate at -20°C
CAS No:
78919-13-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Novel mode of action of iloprost: in vitro down-regulaton of endothelial cell adhesion molecules.
    Della Bella et al.
    Prostaglandins Other Lipid Mediat., 2001;65:73
  2. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs.
    Abramovitz et al.
    Biochim.Biophys.Acta, 2000;1483:285
  3. The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK 36 374) - equipotent to PGI2 in vitro.
    Schror et al.
    Naunyn-Schmied.Arch.Pharmacol., 1981;316:252

Product Datasheets

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Citations for Iloprost

The citations listed below are publications that use Tocris products. Selected citations for Iloprost include:

2 Citations: Showing 1 - 2

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