Catalog Number: 3700
Alternate Names: R 837
Chemical Name: 1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
Biological Activity
Immunomodulator that displays antiviral and antitumor activity. Acts as a Toll-like receptor 7 (TLR7) agonist; stimulates proinflammatory cytokine production and activates NF-κB.
Technical Data
  • M.Wt:
    240.3
  • Formula:
    C14H16N4
  • Solubility:
    Soluble to 5 mM in DMSO with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    99011-02-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The antitumoral mode of action of imiquimod and other imidazoquinolines.
    Schon and Schon
    Curr.Med.Chem., 2007;14:681
  2. The pharmacology of endosomal TLR agonists in viral disease.
    Averett et al.
    Biochem.Soc.Trans., 2007;35:1468
  3. A review of the applications of imiquimod: a novel immune response modifier.
    Syed et al.
    Exp.Opin.Pharmacother., 2001;2:877

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