Chemical Name: 4-(1H-Imidazol-4-ylmethyl)piperidine dihydrobromide
Biological ActivityImmepip dihydrobromide is a potent histamine H3 receptor agonist. Also binds to H4 receptors (Ki values are 0.4 and 9 nM at human recombinant H3 and H4 receptors respectively). Equipotent to or slightly more active than (R)-α-methylhistamine at H3 receptors.
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Cardiovascular effects of selective agonists and antagonists of histamine H3 receptors in the anaesthetized rat.
Coruzzi et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1995;351:569
Cloning and pharmacological characterization of a fourth histamine receptor (H4) expressed in bone marrow.
Liu et al.
Mol. Pharmacol., 2001;59:420
A new potent and selective histamine H3 receptor agonist.
Vollinga et al.
Citation for Immepip dihydrobromide
The citations listed below are publications that use Tocris products. Selected citations for Immepip dihydrobromide include:
1 Citation: Showing 1 - 1
Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells.
Authors: Gründemann Et al.
Br J Pharmacol 2002;137:910
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To test the potential role of H4 receptor in the DRG neurons, we first investigated the effects of H4 agonist immepip dihydrobromide (immepip) and histamine to in dissociated DRG neurons.