Catalog Number: 1858
Alternate Names: VUF 4702
Chemical Name: 4-(5-Aminopentyl)imidazole dihydrobromide
Biological Activity
Potent and highly selective histamine H3 receptor antagonist (pA2 = 8.4); displays > 30000-fold selectivity over H1 and H2 receptors. Can act as a partial agonist in SK-N-MC cells expressing human H3 receptors. Produces antinociception, possibly via a non-H1, -H2 or -H3 receptor-mediated mechanism, following central administration in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Antinociceptive activity of impentamine, a histamine congener, after CNS administration.
    Hough et al.
    Life Sci., 1999;64:PL79
  2. Constitutive activity of histamine H3 receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H3 antagonists.
    Wieland et al.
    J.Pharmacol.Exp.Ther., 2001;299:908
  3. Homologs of histamine as histamine H3 receptor antagonists: a new potent and selective H3 antagonist, 4(5)-(5-aminopentyl)-1H-imidazole.
    Vollinga et al.
    J.Med.Chem., 1995;38:266
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