Potent and highly selective histamine H3
receptor antagonist (pA2
= 8.4); displays > 30000-fold selectivity over H1
receptors. Can act as a partial agonist in SK-N-MC cells expressing human H3
receptors. Produces antinociception, possibly via a non-H1
receptor-mediated mechanism, following central administration in vivo
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All Tocris products are intended for laboratory research use only.
Antinociceptive activity of impentamine, a histamine congener, after CNS administration.
Hough et al.
Life Sci., 1999;64:PL79
Constitutive activity of histamine H3 receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H3 antagonists.
Wieland et al.
Homologs of histamine as histamine H3 receptor antagonists: a new potent and selective H3 antagonist, 4(5)-(5-aminopentyl)-1H-imidazole.
Vollinga et al.