Chemical Name: 4-Amino-N'-(3-chloro-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide
Biological ActivityINCB 024360-analog is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50 values are 19 and 67 nM in enzymatic activity and HeLa cell assays, respectively). Decreases kynurenine levels in plasma and reduces tumor growth in vivo. Cell membrane permeable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Cancer immunotherapy: selected targets and small-molecule modulators.
Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model.
Yue et al.
Challenges and opportunities in the discovery of new therapeutics targeting the kynurenine pathway.
Dounay et al.
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