INCB 024360-analog

Key Product Details

Product Description

INCB 024360-analog is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC₅₀ values are 19 and 67 nM in enzymatic activity and HeLa cell assays, respectively). Decreases kynurenine levels in plasma and reduces tumor growth in vivo. Cell membrane permeable.

Product Specifications for INCB 024360-analog

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for INCB 024360-analog

The following data is based on the product molecular weight 271.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.68 mL	18.41 mL	36.81 mL
5 mM	0.74 mL	3.68 mL	7.36 mL
10 mM	0.37 mL	1.84 mL	3.68 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Yue Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. J.Med.Chem. 2009 PMID: 19507862
• Dounay Challenges and opportunities in the discovery of new therapeutics targeting the kynurenine pathway. J.Med.Chem. 2015 PMID: 26207924
• Weinmann Cancer immunotherapy: selected targets and small-molecule modulators. Chem.Med.Chem. 2016 PMID: 26836578

Product Documents for INCB 024360-analog