INCB 3284 dimesylate (CAS 887401-93-6): R&D Systems
Catalog Number: 4306
Chemical Name: N-[2-[[(3R)-1-[trans-4-Hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamide dimethanesulfonate
Biological Activity
Potent, selective hCCR2 antagonist. Exhibits potent antagonism against monocyte chemoattractant molecule binding to hCCR2 and chemotaxis activity (IC50 values are 3.7 and 4.7 nM respectively). Also displays weak hERG activity; inhibits the hERG potassium current (IC50 = 84μM). Orally bioavailable.
Technical Data
  • M.Wt:
    712.76
  • Formula:
    C26H31F3N4O4.2CH4O3S
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    887401-93-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery of INCB3284, a potent, selective, and orally bioavailable hCCR2 antagonist.
    Xue et al.
    ACS.Med.Chem.Lett., 2011;2:450
Citations:

The citations listed below are publications that use Tocris products. Selected citations for INCB 3284 dimesylate include:

3 Citations: Showing 1 - 3
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  1. Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-β pathways.
    Authors: Liu Et al.
    Cancer Lett. 2016;379:49
  2. Klotho gene deficiency causes salt-sensitive hypertension via monocyte chemotactic protein-1/CC chemokine receptor 2-mediated inflammation.
    Authors: Zhou Et al.
    Nat Commun 2015;26:121
  3. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline.
    Authors: McMillin Et al.
    J Neuroinflammation 2014;11:121

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