Potent, selective hCCR2 antagonist. Exhibits potent antagonism against monocyte chemoattractant molecule binding to hCCR2 and chemotaxis activity (IC50
values are 3.7 and 4.7 nM respectively). Also displays weak hERG activity; inhibits the hERG potassium current (IC50
M). Orally bioavailable.
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All Tocris products are intended for laboratory research use only.
Discovery of INCB3284, a potent, selective, and orally bioavailable hCCR2 antagonist.
Xue et al.
The citations listed below are publications that use Tocris products. Selected citations for INCB 3284 dimesylate include:
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