INCB 3284 dimesylate

Tocris Bioscience | Catalog # 4306

Selective CCR2 antagonist
Tocris Bioscience

Key Product Details

Description

Selective CCR2 antagonist
View all Chemokine Receptor Antagonists »

Product Description

INCB 3284 dimesylate is a potent, selective hCCR2 antagonist. Exhibits potent antagonism against monocyte chemoattractant molecule binding to hCCR2 and chemotaxis activity (IC50 values are 3.7 and 4.7 nM respectively). Also displays weak hERG activity; inhibits the hERG potassium current (IC50 = 84μ M). Orally bioavailable.

Product Specifications for INCB 3284 dimesylate

Molecular Weight

712.76

Formula

C26H31F3N4O4.2CH4O3S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[2-[[(3R)-1-[trans-4-Hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamide dimethanesulfonate

CAS Number

887401-93-6

PubChem ID

11679268

InChI Key

PNPNUHKICDECDH-SEBNIYPMSA-N

SMILES

O=C(NCC(N[C@@H]2CCN([C@H]3CC[C@](C4=CC=C(OC)N=C4)(O)CC3)C2)=O)C1=CC(C(F)(F)F)=CC=C1.CS(=O)(O)=O.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 71.28 100
DMSO 71.28 100

Preparing Stock Solutions for INCB 3284 dimesylate

The following data is based on the product molecular weight 712.76.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.40 mL 7.01 mL 14.03 mL
5 mM 0.28 mL 1.40 mL 2.81 mL
10 mM 0.14 mL 0.70 mL 1.40 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for INCB 3284 dimesylate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for INCB 3284 dimesylate

For research use only

Citations for INCB 3284 dimesylate

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