INCB 3284 dimesylate
Chemical Name: N-[2-[[(3R)-1-[trans-4-Hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamide dimethanesulfonate
Biological ActivityINCB 3284 dimesylate is a potent, selective hCCR2 antagonist. Exhibits potent antagonism against monocyte chemoattractant molecule binding to hCCR2 and chemotaxis activity (IC50 values are 3.7 and 4.7 nM respectively). Also displays weak hERG activity; inhibits the hERG potassium current (IC50 = 84μM). Orally bioavailable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of INCB3284, a potent, selective, and orally bioavailable hCCR2 antagonist.
Xue et al.
Citations for INCB 3284 dimesylate
The citations listed below are publications that use Tocris products. Selected citations for INCB 3284 dimesylate include:
3 Citations: Showing 1 - 3
Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-β pathways.
Authors: Liu Et al.
Cancer Lett. 2016;379:49
Klotho gene deficiency causes salt-sensitive hypertension via monocyte chemotactic protein-1/CC chemokine receptor 2-mediated inflammation.
Authors: Zhou Et al.
Nat Commun 2015;26:121
Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline.
Authors: McMillin Et al.
J Neuroinflammation 2014;11:121
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