INF 39

Name: INF 39
Brand: Tocris Bioscience
SKU: 6341

Tocris Bioscience | Catalog # 6341

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Product Documents

Irreversible NLRP3 inhibitor

Discontinued Product

6341 has been discontinued. View all Inflammasomes Inhibitors products.

Technical Data
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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Irreversible NLRP3 inhibitor

View all Inflammasomes Inhibitors »

Product Description

INF 39 is an irreversible NLRP3 inhibitor (exhibits 52% inhibition of NLRP3 ATPase at 100 μM). Inhibits IL-1β release, caspase activation and pyroptosis in THP-1 cells. Reduces inflammation in a rat colitis model. Exhibits low cytotoxicity.

Product Specifications for INF 39

Molecular Weight

224.68

Formula

C₁₂H₁₃ClO₂

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

Ethyl 2-(2-chlorobenzyl)acrylate

CAS Number

866028-26-4

PubChem ID

69150705

InChI Key

VTAOWWAFBSFWSG-UHFFFAOYSA-N

SMILES

CCOC(C(CC1=C(C=CC=C1)Cl)=C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)

Calculators

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Background References

References are publications that support the biological activity of the product.

Cocco Development of an acrylate derivative targeting the NLRP3 inflammasome for the treatment of inflammatory bowel disease. J.Med.Chem. 2017 PMID: 28410442

Product Documents for INF 39

Certificate of Analysis

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Product Specific Notices for INF 39

For research use only

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