IOX 2

Catalog # Availability Size / Price Qty
4451/10
4451/50
IOX 2 | CAS No. 931398-72-0 | Hydroxylase Inhibitors
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Description: Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor

Chemical Name: N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine

Purity: ≥99%

Product Details
Reviews

Biological Activity

Potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) (IC50 = 21 nM). Displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases JMJD2A, JMJD2C, JMJD2E and JMJD3. Cell permeable.

Technical Data

M.Wt:
352.34
Formula:
C19H16N2O5
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
931398-72-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the IOX 2 probe summary on the SGC website.

Product Datasheets

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