Catalog Number: 5699
Chemical Name: 6-[4-[(2-Methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-isoxazolo[4,5-c]pyridin-4(5H)-one
Biological Activity
Potent Nurr1 activator (EC50 = 3.9 nM). Delays onset and reduces severity of symptoms in mice with experimental autoimmune encephalomyelitis (EAE). Also suppresses NF-κB signaling. Brain penetrant and orally bioavailable.
Technical Data
  • M.Wt:
    390.43
  • Formula:
    C23H22N2O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    500164-74-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of a series of highly potent activators of the Nurr1 signaling pathway.
    Hintermann et al.
    Bioorg.Med.Chem.Lett., 2007;17:193
  2. Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice.
    Montarolo et al.
    PLoS One, 2014;9:e108791

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