Chemical Name: 6-[4-[(2-Methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-isoxazolo[4,5-c]pyridin-4(5H)-one
Biological ActivityIP7e is a potent Nurr1 activator (EC50 = 3.9 nM). Delays onset and reduces severity of symptoms in mice with experimental autoimmune encephalomyelitis (EAE). Also suppresses NF-κB signaling. Brain penetrant and orally bioavailable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of a series of highly potent activators of the Nurr1 signaling pathway.
Hintermann et al.
Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice.
Montarolo et al.
PLoS One, 2014;9:e108791
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for IP7e
There are currently no reviews for this product. Be the first to review IP7e and earn rewards!
Have you used IP7e?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image