Catalog Number: 1869
Alternate Names: TVX Q 7821
Chemical Name: 2-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3(2H)-one-1,1-dioxide
Biological Activity
Selective 5-HT1A receptor agonist (Ki = 10 nM). Anxiolytic in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Central action of ipsapirone, a new anxiolytic drug, on serotoninergic, noradrenergic and dopaminergic functions.
    Maj et al.
    J.Neural.Transm., 1987;70:1
  2. Brain serotonin receptors as a target for the putative anxiolytic TVX Q 7821.
    Traber et al.
    Brain Res.Bull., 1984;12:741
  3. Binding of the putative anxiolytic TVX Q 7821 to hippocampal 5-hydroxytryptamine (5-HT) recognition sites.
    Glaser and Traber
    Naunyn-Schmied.Arch.Pharmacol., 1985;329:211

The citations listed below are publications that use Tocris products. Selected citations for Ipsapirone include:

Showing Results 1 - 1 of 1

  1. Uncontrollable, but not controllable, stress desensitizes 5-HT1A receptors in the dorsal raphe nucleus.
    Authors: Rozeske Et al.
    J Neurosci
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