IRL-1620

  ( 6 citations )    
Product Datasheet
Catalog Number:1196
Chemical Name:
Product Details
Citations (6)
Supplemental Products
Reviews
Biological Activity
Highly selective ETB endothelin receptor agonist (Ki values are 0.016 and 1900 nM at ETB and ETA receptors respectively). Discriminates two subpopulations of ETB receptors.
Technical Data
  • M.Wt:
    1820
  • Formula:
    C86H117N17O27
  • Sequence:
    DEEAVYFAHLDIIW

    (Modifications: Asp-1 = Suc-Asp)

  • Solubility:
    Soluble to 0.70 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    142569-99-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for IRL-1620 include:

6 Citations: Showing 1 - 6
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  1. Increased cerebrovascular sensitivity to endothelin-1 in a rat model of obstructive sleep apnea: a role for endothelin receptor B.
    Authors: Durgan Et al.
    J Cereb Blood Flow Metab  2015;35:402
  2. Modulation by endothelin-1 of spontaneous activity and membrane currents of atrioventricular node myocytes from the rabbit heart.
    Authors: Choisy Et al.
    PLoS One  2012;7:e33448
  3. Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors.
    Authors: Hamby Et al.
    Purinergic Signal  2012;32:14489
  4. Interleukin-10 attenuates vascular responses to endothelin-1 via effects on ERK1/2-dependent pathway.
    Authors: Giachini Et al.
    Am J Physiol Heart Circ Physiol  2009;296:H489
  5. Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice.
    Authors: McQueen Et al.
    Br J Pharmacol  2007;151:278
  6. Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon.
    Authors: Khan Et al.
    Br J Pharmacol  2006;147:607

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