IRL-1620

Tocris Bioscience | Catalog # 1196

Highly selective ETB agonist
Tocris Bioscience
Discontinued Product
1196 has been discontinued. View all Endothelin ETB Receptor Agonists products.

Key Product Details

Description

Highly selective ETB agonist
View all Endothelin ETB Receptor Agonists »

Product Description

IRL-1620 is a potent and highly selective ETB endothelin receptor agonist (Ki values are 0.016 and 1900 nM at ETB and ETA receptors respectively). Discriminates two subpopulations of ETB receptors. IRL-1620 prevents oxidative stress and cognitive impairment induced by Aβ in normal and diabetic rats; in a rat brain ischemia model it is neuroprotective, increases angiogenesis and neurogenesis, and promotes the recovery of neuronal function. Also promotes neural progenitor cell differentiation and maturation in vivo and in vitro.

Product Specifications for IRL-1620

Molecular Weight

1820.00

Formula

C86H117N17O27

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

142569-99-1

PubChem ID

16130933

InChI Key

DXPHNGAMYPPTBJ-TZMIJSMNSA-N

SMILES

CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CCC(O)=O)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 0.7mg/ml in water

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Product Documents for IRL-1620

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for IRL-1620

For research use only

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