Catalog Number: 0235
Chemical Name: 1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride
Biological Activity
Specific GABAA receptor agonist. Suppresses low magnesium induced seizure like events in organotypic hippocampal brain slices.
Technical Data
  • M.Wt:
    163.6
  • Formula:
    C6H9NO2.HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    68547-97-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds.
    Krogsgaard-Larsen et al.
    J.Neurochem., 1978;30:1377
  2. Dihydromuscimol, thiomuscimol and related heterocyclic compounds as GABA analogues.
    Krogsgaard-Larsen et al.
    J.Neurochem., 1979;32:1717
  3. Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures.
    Wahab et al.
    Epilepsy Res., 2009;86:113
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Isoguvacine hydrochloride include:

5 Citations: Showing 1 - 5
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  1. Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2).
    Authors: Edwards Et al.
    Biochim Biophys Acta 2011;1808:260
  2. A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons.
    Authors: Lobb Et al.
    J Neurophysiol 2010;104:403
  3. Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus.
    Authors: Sipilä Et al.
    J Neurosci 2009;29:6982
  4. Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release.
    Authors: Long Et al.
    Br J Pharmacol 2009;284:8726
  5. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen.
    Authors: Wood Et al.
    J Neurosci 2000;131:1050

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