ITD 1

  ( 1 citations )    
Product Datasheet
Catalog Number:5068
Chemical Name:4-[1,1'-Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester
Product Details
Citations (1)
Reviews
Biological Activity
Selective inhibitor of TGF-β signaling (IC50 = 0.85 μM); displays little or no inhibition of activin, Wnt or BMP signaling pathways. Induces proteasomal degradation of the TGF-β type II receptor. Inhibits TGF-β-induced mesoderm formation from mouse embryonic stem cells (ESCs) during early differentiation; selectively promotes the differentiation of ESCs to cardiomyocytes in vitro between days 3-5. Does not induce differentiation of vascular smooth muscle cells or endothelial cells.
Technical Data
  • M.Wt:
    415.52
  • Formula:
    C27H29NO3
  • Solubility:
    Soluble to 20 mM in DMSO and to 10 mM in ethanol with gentle warming
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    1099644-42-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ITD 1 include:

1 Citations: Showing 1 - 1

  1. TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus.
    Authors: Smyth
    Int J Parasitol  2018;48(5):379

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