Selective inhibitor of TGF-β
= 0.85 μ
M); displays little or no inhibition of activin, Wnt or BMP signaling pathways. Induces proteasomal degradation of the TGF-β
type II receptor. Inhibits TGF-β
-induced mesoderm formation from mouse embryonic stem cells (ESCs) during early differentiation; selectively promotes the differentiation of ESCs to cardiomyocytes in vitro
between days 3-5. Does not induce differentiation of vascular smooth muscle cells or endothelial cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Small molecule-mediated TGF-� type II receptor degradation promotes cardiomyogenesis in embryonic stem cells.
Willems et al.
Cell Stem Cell, 2012;11:242
Emerging strategies for spatiotemporal control of stem cell fate and morphogenesis.
Kinney et al.
Trends Biotechnol., 2013;31:78