ITD 1

Key Product Details

Product Description

ITD 1 is a selective inhibitor of TGF-β signaling (IC₅₀ = 0.85 μM); displays little or no inhibition of activin, Wnt or BMP signaling pathways. Induces proteasomal degradation of the TGF-β type II receptor. Inhibits TGF-β-induced mesoderm formation from mouse embryonic stem cells (ESCs) during early differentiation; selectively promotes the differentiation of ESCs to cardiomyocytes in vitro between days 3-5. Does not induce differentiation of vascular smooth muscle cells or endothelial cells.

Product Specifications for ITD 1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ITD 1

The following data is based on the product molecular weight 415.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.03 mL	60.17 mL	120.33 mL
1 mM	2.41 mL	12.03 mL	24.07 mL
2 mM	1.20 mL	6.02 mL	12.03 mL
10 mM	0.24 mL	1.20 mL	2.41 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

• Kinney Emerging strategies for spatiotemporal control of stem cell fate and morphogenesis. Trends Biotechnol. 2013 PMID: 23219200
• Willems Small molecule-mediated TGF-beta type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell 2012 PMID: 22862949

Product Documents for ITD 1