ITD 1

Catalog # Availability Size / Price Qty
5068/10
5068/50
ITD 1 | CAS No. 1099644-42-4 | Compounds for Stem Cell Differentiation
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Description: Selective inhibitor of TGF-β signaling; induces cardiomyocyte differentiation in ESCs

Chemical Name: 4-[1,1'-Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

ITD 1 is a selective inhibitor of TGF-β signaling (IC50 = 0.85 μM); displays little or no inhibition of activin, Wnt or BMP signaling pathways. Induces proteasomal degradation of the TGF-β type II receptor. Inhibits TGF-β-induced mesoderm formation from mouse embryonic stem cells (ESCs) during early differentiation; selectively promotes the differentiation of ESCs to cardiomyocytes in vitro between days 3-5. Does not induce differentiation of vascular smooth muscle cells or endothelial cells.

Technical Data

M.Wt:
415.52
Formula:
C27H29NO3
Solubility:
Soluble to 20 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1099644-42-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for ITD 1

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