Compounds for Stem Cell Differentiation: Products

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Stem cells have the ability to differentiate into specialized cell subtypes depending upon their level of potency. For instance, embryonic and induced pluripotent stem cells can give rise to cells of all three germ layers: ectoderm, mesoderm, and endoderm. Adult stem cells are generally considered to have limited potency and differentiate into a restricted number of cell types. In order to generate populations of specialized cell types for regenerative medicine, drug screening, or disease and development models, researchers must control and direct the differentiation of stem cells. Cell fate decisions can be directed by natural or chemically synthesized small molecules. For instance, a specific inhibitor of glycogen synthase kinase-3 beta can induce neuronal differentiation in pluripotent stem cells. Combinations of specific cytokines and sodium butyrate, a histone deacetylase inhibitor, have been shown to direct the differentiation of stem cells into hepatocytes. Tocris provides a complete range of bioactive small molecules to control the differentiation of stem cells into defined derivatives.

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DMSO, sterile filtered 

DMSO, sterile filtered, wide ranging applications in cell culture, cryopreservation and organic chemistry. Solvent for polar and nonpolar compounds

DAPT 

Gamma γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling

Forskolin 

Adenylyl cyclase activator

LDN 193189 dihydrochloride 

Potent and selective ALK2 and ALK3 inhibitor; inhibits BMP4 signaling; promotes neural induction of hPSCs

Dorsomorphin dihydrochloride 

Potent AMPK inhibitor; also BMP type I receptor inhibitor

Retinoic acid 

Endogenous retinoic acid receptor agonist

DMH-1 

Selective ALK2 inhibitor

1-Oleoyl lysophosphatidic acid sodium salt 

Endogenous agonist of LPA1 and LPA2

Dexamethasone 

Anti-inflammatory glucocorticoid

IBMX 

PDE inhibitor (non-selective)

Purmorphamine 

Smo receptor agonist

SP 600125 

Selective JNK inhibitor

Metformin hydrochloride 

Activator of LKB1/AMPK; antidiabetic agent

A 769662 

Potent AMPK activator

AICAR 

AMPK activator

AMD 3100 octahydrochloride 

Highly selective CXCR4 antagonist

Fluoxetine hydrochloride 

5-HT reuptake inhibitor

PD 173074 

FGFR1 and -3 inhibitor

5-Azacytidine 

DNA methyltransferase inhibitor

IWP 4 

Potent inhibitor of Wnt/β-catenin signaling

CKI 7 dihydrochloride 

CK1 inhibitor

T3 

Thyroid hormone; also promotes differentiation of oligodendroglial precursor cells

Sodium butyrate 

Histone deacetylase inhibitor

IDE 1 

Induces definitive endoderm formation in mouse and human ESCs

ISX 9 

Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation

TWS 119 

GSK-3β inhibitor; induces neuronal differentiation in ESCs

IDE 2 

Induces definitive endoderm formation in mouse and human ESCs

A 939572 

Potent SCD-1 inhibitor

ITD 1 

Selective inhibitor of TGF-β signaling; induces cardiomyocyte differentiation in ESCs

SIS3 

Selective Smad3 inhibitor; inhibits TGF-βR1 signaling

2-Phospho-L-ascorbic acid trisodium salt 

Ascorbic acid derivative; maintains differentiation potential in bone marrow-derived MSCs

BOP 

Dual α9β1/α4β1 integrin inhibitor; preferentially mobilizes HSCs

Lin28 1632 

RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor

CHIR 98014 

Highly potent and selective GSK-3 inhibitor

Zebularine 

DNA methyltransferase and cytidine deaminase inhibitor

Thioridazine hydrochloride 

Dopamine receptor antagonist; antipsychotic

Neurodazine 

Induces neurogenesis in mature skeletal muscle cells

Stauprimide 

Inhibits NME2 nuclear translocation; primes ESCs for differentiation

Cardiogenol C hydrochloride 

Induces cardiomyocyte differentiation in ESCs

TCS 2210 

Inducer of neuronal differentiation in MSCs

EC 23 

Synthetic retinoid; induces differentiation of stem cells

Cardionogen 1 

Inhibitor of Wnt/β-catenin signaling

Kartogenin 

Potently induces chondrogenesis in MSCs

PluriSln 1 

SCD-1 inhibitor

KHS 101 hydrochloride 

Selective inducer of neuronal differentiation in hippocampal neural progenitors

GSA 10 

Smo receptor agonist

Shz 1 

Activator of early cardiac genes in pluripotent stem cells; induces differentiation in M-PBMCs

Neuropathiazol 

Selective inducer of neuronal differentiation in hippocampal neural progenitors

CCG 1423 

Rho/SRF pathway inhibitor; induces intermediate mesoderm differentiation from ESCs

FH 1 

Enhances iPSC-derived hepatocyte differentiation and maturation
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