Compounds for Stem Cell Differentiation: Products

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Stem cells have the ability to differentiate into specialized cell subtypes depending upon their level of potency. For instance, embryonic and induced pluripotent stem cells can give rise to cells of all three germ layers: ectoderm, mesoderm, and endoderm. Adult stem cells are generally considered to have limited potency and differentiate into a restricted number of cell types. In order to generate populations of specialized cell types for regenerative medicine, drug screening, or disease and development models, researchers must control and direct the differentiation of stem cells. Cell fate decisions can be directed by natural or chemically synthesized small molecules. For instance, a specific inhibitor of glycogen synthase kinase-3 beta can induce neuronal differentiation in pluripotent stem cells. Combinations of specific cytokines and sodium butyrate, a histone deacetylase inhibitor, have been shown to direct the differentiation of stem cells into hepatocytes. Tocris provides a complete range of bioactive small molecules to control the differentiation of stem cells into defined derivatives.

"Compounds for Stem Cell Differentiation" has 62 results in Products.
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Forskolin

Adenylyl cyclase activator

DAPT

γ-secretase inhibitor

Dorsomorphin dihydrochloride

Potent AMPK inhibitor

IBMX

PDE inhibitor (non-selective)

Metformin hydrochloride

Activator of LKB1/AMPK; antidiabetic agent

DMH-1

Selective ALK2 inhibitor

Retinoic acid

Endogenous retinoic acid receptor agonist

AICAR

AMPK activator

LDN 193189 dihydrochloride

Potent and selective ALK2 and ALK3 inhibitor; promotes neural induction of hPSCs

Dexamethasone

Anti-inflammatory glucocorticoid

SP 600125

Selective JNK inhibitor

AMD 3100 octahydrochloride

Highly selective CXCR4 antagonist

1-Oleoyl lysophosphatidic acid sodium salt

Endogenous agonist of LPA1 and LPA2

Purmorphamine

Smo receptor agonist

Fluoxetine hydrochloride

5-HT reuptake inhibitor

A 769662

Potent AMPK activator

IWP 4

Potent inhibitor of Wnt/β-catenin signaling

Lin28 1632

RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor

PD 173074

FGFR1 and -3 inhibitor

5-Azacytidine

DNA methyltransferase inhibitor

IDE 1

Induces definitive endoderm formation in mouse and human ESCs

ISX 9

Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation

SIS3

Selective Smad3 inhibitor; inhibits TGF-βR1 signaling

KY 02111

Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes

Sodium butyrate

Histone deacetylase inhibitor

TCS 2210

Inducer of neuronal differentiation in MSCs

IDE 2

Induces definitive endoderm formation in mouse and human ESCs

Kartogenin

Potently induces chondrogenesis in MSCs

A 939572

Potent SCD-1 inhibitor

ITD 1

Selective inhibitor of TGF-β signaling; induces cardiomyocyte differentiation in ESCs

Isotretinoin

Endogenous agonist for retinoic acid receptors; inducer of neuronal differentiation

Liothyronine sodium

Thyroid hormone (T3) analog; also promotes adipogenic differentiation of MSCs

SW 033291

High affinity 15-PGDH inhibitor; promotes hematopoiesis and hepatocyte proliferation

2-Phospho-L-ascorbic acid trisodium salt

Ascorbic acid derivative; maintains differentiation potential in bone marrow-derived MSCs

P7C3

NAMPT activator; also proneurogenic and neuroprotective

Strontium chloride

Calcium sensing receptor (CaSR) agonist

Zebularine

DNA methyltransferase and cytidine deaminase inhibitor

Thioridazine hydrochloride

Dopamine receptor antagonist; antipsychotic

Neurodazine

Induces neurogenesis in mature skeletal muscle cells

Stauprimide

Inhibits NME2 nuclear translocation; primes ESCs for differentiation

TWS 119

GSK-3β inhibitor; induces neuronal differentiation in ESCs

Cardiogenol C hydrochloride

Induces cardiomyocyte differentiation in ESCs

EC 23

Synthetic retinoid; induces differentiation of stem cells

Cardionogen 1

Inhibitor of Wnt/β-catenin signaling

PluriSln 1

SCD-1 inhibitor

KHS 101 hydrochloride

Selective inducer of neuronal differentiation in hippocampal neural progenitors

GSA 10

Smo receptor agonist

Shz 1

Activator of early cardiac genes in pluripotent stem cells; induces differentiation in M-PBMCs

Neuropathiazol

Selective inducer of neuronal differentiation in hippocampal neural progenitors
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