Compounds for Stem Cell Differentiation: Products

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Stem cells have the ability to differentiate into specialized cell subtypes depending upon their level of potency. For instance, embryonic and induced pluripotent stem cells can give rise to cells of all three germ layers: ectoderm, mesoderm, and endoderm. Adult stem cells are generally considered to have limited potency and differentiate into a restricted number of cell types. In order to generate populations of specialized cell types for regenerative medicine, drug screening, or disease and development models, researchers must control and direct the differentiation of stem cells. Cell fate decisions can be directed by natural or chemically synthesized small molecules. For instance, a specific inhibitor of glycogen synthase kinase-3 beta can induce neuronal differentiation in pluripotent stem cells. Combinations of specific cytokines and sodium butyrate, a histone deacetylase inhibitor, have been shown to direct the differentiation of stem cells into hepatocytes. Tocris provides a complete range of bioactive small molecules to control the differentiation of stem cells into defined derivatives.

"Compounds for Stem Cell Differentiation" has 66 results in Products.
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Gamma γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling

DMSO, sterile filtered 

DMSO, sterile filtered, wide ranging applications in cell culture, cryopreservation and organic chemistry. Solvent for polar and nonpolar compounds


Adenylyl cyclase activator

LDN 193189 dihydrochloride 

Potent and selective ALK2 and ALK3 inhibitor; inhibits BMP4 signaling; promotes neural induction of hPSCs

Dorsomorphin dihydrochloride 

Potent AMPK inhibitor; also BMP type I receptor inhibitor


Selective ALK2 inhibitor

Retinoic acid 

Endogenous retinoic acid receptor agonist


High affinity PKC activator; also APP modulator


Anti-inflammatory glucocorticoid


AMPK activator


PDE inhibitor (non-selective)

Metformin hydrochloride 

Activator of LKB1/AMPK; antidiabetic agent

SP 600125 

Selective JNK inhibitor

1-Oleoyl lysophosphatidic acid sodium salt 

Endogenous agonist of LPA1 and LPA2


Smo receptor agonist

Fluoxetine hydrochloride 

5-HT reuptake inhibitor

A 769662 

Potent AMPK activator


Thyroid hormone; also promotes differentiation of oligodendroglial precursor cells

AMD 3100 octahydrochloride 

Highly selective CXCR4 antagonist


DNA methyltransferase inhibitor

IWP 4 

Potent inhibitor of Wnt/β-catenin signaling

PD 173074 

FGFR1 and -3 inhibitor

EC 23 

Synthetic retinoid; induces differentiation of stem cells

ISX 9 

Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation

Lin28 1632 

RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor

CHIR 98014 

Highly potent and selective GSK-3 inhibitor

Thioridazine hydrochloride 

Dopamine receptor antagonist; antipsychotic

Sodium butyrate 

Histone deacetylase inhibitor

IDE 1 

Induces definitive endoderm formation in mouse and human ESCs

IDE 2 

Induces definitive endoderm formation in mouse and human ESCs

PluriSln 1 

SCD-1 inhibitor


Selective Smad3 inhibitor; inhibits TGF-βR1 signaling

CKI 7 dihydrochloride 

CK1 inhibitor

2-Phospho-L-ascorbic acid trisodium salt 

Ascorbic acid derivative; maintains differentiation potential in bone marrow-derived MSCs

AS 1842856 

Potent and selective Foxo1 inhibitor; orally bioavailable


Dual α9β1/α4β1 integrin inhibitor; preferentially mobilizes HSCs

RCGD 423 

gp130 modulator; activates JAK/STAT signaling


DNA methyltransferase and cytidine deaminase inhibitor


Induces neurogenesis in mature skeletal muscle cells

TWS 119 

GSK-3β inhibitor; induces neuronal differentiation in ESCs

Cardiogenol C hydrochloride 

Induces cardiomyocyte differentiation in ESCs

TCS 2210 

Inducer of neuronal differentiation in MSCs

Cardionogen 1 

Inhibitor of Wnt/β-catenin signaling


Potently induces chondrogenesis in MSCs

A 939572 

Potent SCD-1 inhibitor

KHS 101 hydrochloride 

Selective inducer of neuronal differentiation in hippocampal neural progenitors

GSA 10 

Smo receptor agonist

ITD 1 

Selective inhibitor of TGF-β signaling; induces cardiomyocyte differentiation in ESCs


Selective inducer of neuronal differentiation in hippocampal neural progenitors

CCG 1423 

Rho/SRF pathway inhibitor; induces intermediate mesoderm differentiation from ESCs
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