Selective inhibitor of TrioN RhoGEF activity. Inhibits TrioN-mediated GTP exchange on RhoG and Rac1, formation of TrioN-induced cellular structures in REF52 fibroblasts and NGF-mediated neurite outgrowth in PC12 cells in vitro
Soluble to 5 mM in DMSO
Store at +4°C
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A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway.
Bouquier et al.