Home / Deubiquitinating Enzyme Inhibitors / IU1-47

IU1-47

Catalog #: 6443 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6443/50
6443/10
IU1-47 | CAS No. 670270-31-2 | Deubiquitinating Enzyme Inhibitors
1 Image
Description: Potent USP14 inhibitor

Chemical Name: 1-[1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-piperidinyl)ethanone

Purity: ≥98%

Product Details
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

IU1-47 is a potent USP14 inhibitor (IC50 = 60 nM). Demonstrates >30-fold selectivity for USP14 over USP5 (IsoT). Enhances degradation of proteasome substrates in vitro. Increases degradation of wild type and pathological tau in MEFs, primary neuronal cultures and human iPSC derived neurons.

Technical Data

M.Wt:
330.85
Formula:
C19H23ClN2O
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
670270-31-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.
    Boselli M, Lee BH, Robert J et al.
    J. Biol. Chem.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for IU1-47

There are currently no reviews for this product. Be the first to review IU1-47 and earn rewards!

Have you used IU1-47?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.