IU1-47

Catalog # Availability Size / Price Qty
6443/50
6443/10
Cat.No. 6443 - IU1-47 | C19H23ClN2O | CAS No. 670270-31-2
1 Image
Description: Potent USP14 inhibitor

Chemical Name: 1-[1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-piperidinyl)ethanone

Purity: ≥98%

Product Details
Reviews

Biological Activity

Potent USP14 inhibitor (IC50 = 60 nM). Demonstrates >30-fold selectivity for USP14 over USP5 (IsoT). Enhances degradation of proteasome substrates in vitro. Increases degradation of wild type and pathological tau in MEFs, primary neuronal cultures and human iPSC derived neurons.

Technical Data

M.Wt:
330.85
Formula:
C19H23ClN2O
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
670270-31-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.
    Boselli M, Lee BH, Robert J et al.
    J. Biol. Chem.

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