Ivabradine hydrochloride

Catalog # Availability Size / Price Qty
6542/50
6542/10
Cat.No. 6542 - Ivabradine hydrochloride | C27H36N2O5.HCl | CAS No. 148849-67-6
1 Image
Description: HCN channel blocker; inhibits If pacemaker current

Chemical Name: 3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride

Purity: ≥98%

Product Details
Reviews (1)

Biological Activity

HCN channel blocker (IC50 is approximately 0.5 - 2.5 μM). Bradycardic agent that inhibits If pacemaker current in sinoatrial node cells.

Technical Data

M.Wt:
505.05
Formula:
C27H36N2O5.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
148849-67-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Ivabradine hydrochloride

Average Rating: 5 (Based on 1 Review)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used Ivabradine hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Effect of ivabradine on pacemaker of human atrial myocytes
By Chintan Koyani on 10/13/2018
Species: Human

Primary human atrial cardiomyocytes were patched to analyze mean current-voltage relationships of pacemaker current (If) before and after ivabradine superfusion (1 μmol/L, 7 min). Ivabradine significantly reduced pacemaker current density (pA/pF) from − 80 to − 130 mV (shown in Image).


Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.