Chemical Name: 3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride
Biological ActivityHCN channel blocker (IC50 is approximately 0.5 - 2.5 μM). Bradycardic agent that inhibits If pacemaker current in sinoatrial node cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49.
Thollon et al.
HCN channel modulators: the need for selectivity.
Novella Romanelli et al.
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Primary human atrial cardiomyocytes were patched to analyze mean current-voltage relationships of pacemaker current (If) before and after ivabradine superfusion (1 μmol/L, 7 min). Ivabradine significantly reduced pacemaker current density (pA/pF) from − 80 to − 130 mV (shown in Image).