Ivermectin

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1260/100
Ivermectin | CAS No. 70288-86-7 | Nicotinic (a7) Receptor Modulators
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Description: Positive allosteric modulator of α7 nAChRs; also positive allosteric modulator of P2X4 receptors

Chemical Name: 22,23-Dihydroavermectin B1

Purity: ≥96%

Product Details
Citations (5)
Supplemental Products
Reviews (1)

Biological Activity

Positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Antihelmintic and antiviral. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM). Inhibits replication of SARS-CoV-2 in vitro (IC50 ~ 2μM).

This product is composed of both Ivermectin B1a (>90%) and Ivermectin B1b.

Technical Data

M.Wt:
875.1
Formula:
C48H74O14 (B1a form)
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥96%
Storage:
Desiccate at +4°C
CAS No:
70288-86-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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Product Datasheets

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Citations for Ivermectin

The citations listed below are publications that use Tocris products. Selected citations for Ivermectin include:

5 Citations: Showing 1 - 5

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P2X4 potentiation
By Anonymous on 10/02/2018
Application: Species: Mouse

Potentiates P2X4 responses in cultured microglia


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