Chemical Name: 22,23-Dihydroavermectin B1
Biological ActivityPositive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Antihelmintic. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM).
This product is composed of both Ivermectin B1a (>90%) and Ivermectin B1b. Deuterated analog also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Allosteric control of gating and kinetics at P2X4 receptor channels.
Khakh et al.
Ivermectin: a positive allosteric effector of the α7 neuronal nicotinic acetylcholine receptor.
Krause et al.
Ivermectin, an unconventional agonist of the glycine receptor chloride channel.
Shan et al.
Activation of rat recombinant α1β2γ2S GABAA receptor by the insecticide iverm.
Adelsberger et al.
Citations for Ivermectin
The citations listed below are publications that use Tocris products. Selected citations for Ivermectin include:
4 Citations: Showing 1 - 4
Ginsenosides Act As Positive Modulators of P2X4 Receptors.
Authors: Dhuna Et al.
Mol Pharmacol 2019;95:210
A biofidelic 3D culture model to study the development of brain cellular systems.
Authors: Ren Et al.
Pharmacol Res Perspect 2016;6:24953
Natural compounds with P2X7 receptor-modulating properties.
Authors: Fischer Et al.
Purinergic Signal 2013;10:313
Positive allosteric modulation by iverm. of human but not murine P2X7 receptors.
Authors: Nörenberg Et al.
Br J Pharmacol 2012;167:48
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Tocris Small Molecules
VersaClone cDNA Plasmids
Reviews for Ivermectin
Average Rating: 5 (Based on 1 Review)
Have you used Ivermectin?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Potentiates P2X4 responses in cultured microglia