Positive allosteric modulator of the α
7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4
receptor. Antihelmintic. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM).
C48H74O14 (B1a form)
Soluble to 50 mM in DMSO
Desiccate at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Kishimoto T et al.
Leucocyte Typing VI. Garland Publishing Inc. London.
Activation of rat recombinant α1β2γ2S GABAA receptor by the insecticide ivermectin.
Adelsberger et al.
Ivermectin: a positive allosteric effector of the α7 neuronal nicotinic acetylcholine receptor.
Krause et al.
Allosteric control of gating and kinetics at P2X4 receptor channels.
Khakh et al.
Ivermectin, an unconventional agonist of the glycine receptor chloride channel.
Shan et al.
The citations listed below are publications that use Tocris products. Selected citations for Ivermectin include:
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