Ivermectin

  ( 3 citations )    
Product Datasheet
Catalog Number:1260
Chemical Name:22,23-Dihydroavermectin B1
Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity
Positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Antihelmintic. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM).

This product is composed of both Ivermectin B1a (>90%) and Ivermectin B1b. Deuterated analog also available.

Technical Data
  • M.Wt:
    875.1
  • Formula:
    C48H74O14 (B1a form)
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >96
  • Storage:
    Desiccate at +4°C
  • CAS No:
    70288-86-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ivermectin include:

3 Citations: Showing 1 - 3
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  1. A biofidelic 3D culture model to study the development of brain cellular systems.
    Authors: Ren Et al.
    Pharmacol Res Perspect  2016;6:24953
  2. Natural compounds with P2X7 receptor-modulating properties.
    Authors: Fischer Et al.
    Purinergic Signal  2013;10:313
  3. Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors.
    Authors: Nörenberg Et al.
    Br J Pharmacol  2012;167:48

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