Catalog Number: 1260
Chemical Name: 22,23-Dihydroavermectin B1
Biological Activity

Positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Antihelmintic. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM).

This product is composed of both Ivermectin B1a (>90%) and Ivermectin B1b.

Deuterated analog also available.
Technical Data
  • M.Wt:
    875.1
  • Formula:
    C48H74O14 (B1a form)
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >96%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    70288-86-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Activation of rat recombinant α1β2γ2S GABAA receptor by the insecticide ivermectin.
    Adelsberger et al.
    Eur.J.Pharmacol., 2000;394:163
  3. Ivermectin: a positive allosteric effector of the α7 neuronal nicotinic acetylcholine receptor.
    Krause et al.
    Mol.Pharmacol., 1998;53:283
  4. Allosteric control of gating and kinetics at P2X4 receptor channels.
    Khakh et al.
    J.Neurosci., 1999;19:7289
  5. Ivermectin, an unconventional agonist of the glycine receptor chloride channel.
    Shan et al.
    J.Biol.Chem., 2001;276:12556
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ivermectin include:

2 Citations: Showing 1 - 2
Filter your results:

  1. A biofidelic 3D culture model to study the development of brain cellular systems.
    Authors: Ren Et al.
    Pharmacol Res Perspect 2016;6:24953
  2. Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors.
    Authors: Nörenberg Et al.
    Br J Pharmacol 2012;167:48
Tocris Small Molecules
Description Application Cat# Citations Images  

Ivermectin B1a-d2

5156  
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