Catalog # Availability Size / Price Qty
Ivermectin | CAS No. 70288-86-7 | Nicotinic (a7) Receptor Modulators
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Description: Positive allosteric modulator of α7 nAChRs; also positive allosteric modulator of P2X4 receptors

Chemical Name: 22,23-Dihydroavermectin B1

Purity: ≥96%

Product Details
Citations (4)
Supplemental Products
Reviews (1)

Biological Activity

Positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Antihelmintic. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM).

This product is composed of both Ivermectin B1a (>90%) and Ivermectin B1b. Deuterated analog also available.

Technical Data

C48H74O14 (B1a form)
Soluble to 50 mM in DMSO
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Ivermectin

The citations listed below are publications that use Tocris products. Selected citations for Ivermectin include:

4 Citations: Showing 1 - 4

  1. Ginsenosides Act As Positive Modulators of P2X4 Receptors.
    Authors: Dhuna Et al.
    Mol Pharmacol  2019;95:210
  2. A biofidelic 3D culture model to study the development of brain cellular systems.
    Authors: Ren Et al.
    Pharmacol Res Perspect  2016;6:24953
  3. Natural compounds with P2X7 receptor-modulating properties.
    Authors: Fischer Et al.
    Purinergic Signal  2013;10:313
  4. Positive allosteric modulation by iverm. of human but not murine P2X7 receptors.
    Authors: Nörenberg Et al.
    Br J Pharmacol  2012;167:48


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P2X4 potentiation
By Anonymous on 10/02/2018
Species: Mouse

Potentiates P2X4 responses in cultured microglia

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