IWP 12

Key Product Details

Product Description

IWP 12 is a potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC₅₀ = 15 nM). Inhibits Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways. Blocks zebrafish tailfin regeneration in vivo.

Product Specifications for IWP 12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for IWP 12

The following data is based on the product molecular weight 418.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.39 mL	11.95 mL	23.89 mL
5 mM	0.48 mL	2.39 mL	4.78 mL
10 mM	0.24 mL	1.19 mL	2.39 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Dodge Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine. J.Biol.Chem. 2012 PMID: 22593577

Product Documents for IWP 12