Catalog # Availability Size / Price Qty
IWP 4 | CAS No. 686772-17-8 | beta-Catenin Inhibitors
1 Image
Description: Potent inhibitor of Wnt/β-catenin signaling

Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide

Purity: ≥98%

Product Details
Citations (15)
Supplemental Products
Reviews (1)

Biological Activity

IWP 4 is a potent inhibitor of Wnt/β-catenin signaling (IC50 = 25 nM). Has minimal effect on Notch and Hedgehog signaling pathways. Induces differentiation of cardiomyocytes from human ESCs and iPSCs.

Technical Data

Soluble to 1 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for IWP 4

The citations listed below are publications that use Tocris products. Selected citations for IWP 4 include:

15 Citations: Showing 1 - 10

  1. Lipid droplet-associated lncRNA LIPTER preserves cardiac lipid metabolism.
    Authors: Shiyong Et al.
    Nat Cell Biol  2023;
  2. Engineering a living cardiac pump on a chip using high-precision fabrication.
    Authors: Kamil Et al.
    Sci Adv  2022;8:eabm3791
  3. Transcription factor protein interactomes reveal genetic determinants in heart disease.
    Authors: Christine E Et al.
    Cell  2022;185:794-814.e30
  4. Co-differentiation and Co-maturation of Human Cardio-pulmonary Progenitors and Micro-Tissues from Human Induced Pluripotent Stem Cells.
    Authors: Wai Hoe Et al.
    Bio Protoc  2022;12:e4488
  5. Recapitulating human cardio-pulmonary co-development using simultaneous multilineage differentiation of pluripotent stem cells.
    Authors: Ming Et al.
    Elife  2022;11
  6. SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway.
    Authors: Andrew Et al.
    J Virol  2021;95:e0086221
  7. Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2.
    Authors: J Travis Et al.
    Cell Rep  2021;36:109512
  8. Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment.
    Authors: Paul Et al.
    Cell Rep  2021;35:109088
  9. Replating Protocol for Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
    Authors: Esra Et al.
    Methods Mol Biol  2021;2520:161-170
  10. Using hiPSC-CMs to Examine Mechanisms of Catecholaminergic Polymorphic Ventricular Tachycardia.
    Authors: Parisa Et al.
    Curr Protoc  2021;1:e320


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

VersaClone cDNA Plasmids

Reviews for IWP 4

Average Rating: 4 (Based on 1 Review)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used IWP 4?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

would use again
By Anonymous on 05/10/2018

colleague used for an experiment

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.