Catalog Number: 5214
Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Biological Activity
Potent inhibitor of Wnt/β-catenin signaling (IC50 = 25 nM). Has minimal effect on Notch and Hedgehog signaling pathways. Induces differentiation of cardiomyocytes from human ESCs and iPSCs.
Technical Data
  • M.Wt:
    496.62
  • Formula:
    C23H20N4O3S3
  • Solubility:
    Soluble to 10 mM in DMSO with sonication
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    686772-17-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling.
    Lian et al.
    Proc.Natl.Acad.Sci.U S A, 2012;109:E1848
  2. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
    Chen et al.
    Nat.Chem.Biol., 2009;5:100
  3. Differentiation of human epidermal neural crest stem cells (hEPI-NCSC) into virtually homogenous populations of dopaminergic neurons.
    Narytnyk et al.
    Stem Cell Rev., 2014;10:316

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