Chemical Name: (1'S,2S)-4-Amino-N-(1'-carbamoyl-2'-phenylethyl)-2-(4"-methyl-1"-naphthalenesulfonylamino)butanamide trifluoroacetate
Biological ActivityHigh affinity human somatostatin receptor 4 (sst4) agonist (Ki = 1.2 nM). Displays >400-fold selectivity for human sst4 over other human sst receptor subtypes. Exhibits 2 to 3-fold more potent agonism in vitro than endogenous ligands somatostatin-14 (Cat. No. 1157) and somatostatin-28 (Cat. No. 1165). Reduces inflammatory airway hyperresponsiveness in acute and chronic airway inflammation models in mice. Exhibits anxiolytic effects in elevated plus maze test in mice.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouse.
Elekes et al.
Superagonism at the human somatostatin receptor subtype 4.
Engström et al.
Somatostatin receptor subtype 4 activation is involved in anxiety and depression-like behavior in mouse models.
Scheich et al.
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