Chemical Name: 2-Methyl-5-(2-thienyl)-3-furancarboxylic acid
Biological ActivityPiezo1 channel activator. Promotes Ca2+ influx into HEK293 cells expressing Piezo1 channels. Elicits responses in mouse Piezo1-transfected, but not Piezo2-transfected cells.
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A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel.
Wang et al.
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