Chemical Name: 2-Methyl-5-(2-thienyl)-3-furancarboxylic acid
Biological ActivityPiezo1 channel activator. Promotes Ca2+ influx into HEK293 cells expressing Piezo1 channels. Elicits responses in mouse Piezo1-transfected, but not Piezo2-transfected cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel.
Wang et al.
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