JIB 04

Catalog # Availability Size / Price Qty
4972/10
4972/50
Cat.No. 4972 - JIB 04 | C17H13ClN4 | CAS No. 199596-05-9
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Description: Pan Jumonji inhibitor; active in vivo

Chemical Name: 5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

Pan Jumonji histone demethylase inhibitor (IC50 values are 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively). Exhibits negligible activity at PHD2 and TET1. Selectively blocks cancer cell growth in vitro and diminishes tumor growth in H358 and A549 mouse xenograft models in vivo. Prolongs survival in a mouse model of breast cancer.

Technical Data

M.Wt:
308.76
Formula:
C17H13ClN4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
199596-05-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citation for JIB 04

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