JMS 17-2 hydrochloride
Chemical Name: 5-[3-[4-(4-Chlorophenyl)-1-piperidinyl]propyl]pyrrolo[1,2-a]quinoxalin-4(5H)-one hydrochloride
Biological ActivityJMS 17-2 hydrochloride is a chemokine CX3CR1 (fractalkine receptor) antagonist. Inhibits fractalkine-induced ERK phosphorylation and decreases migration of breast cancer cells in vitro. Also inhibits circulating tumor cells from seeding into bone and reduces overall tumor burden in a breast cancer metastasis model.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Novel small-molecule CX3CR1 antagonist impairs metastatic seeding and colonization of breast cancer cells.
Shen et al.
Mol. Cancer Res., 2016;14:518
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