JMS 17-2 hydrochloride

Catalog # Availability Size / Price Qty
6378/50
6378/10
JMS 17-2 hydrochloride | Chemokine Receptor Antagonists
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Description: CX3CR1 antagonist

Chemical Name: 5-[3-[4-(4-Chlorophenyl)-1-piperidinyl]propyl]pyrrolo[1,2-a]quinoxalin-4(5H)-one hydrochloride

Purity: ≥98%

Product Details
Reviews

Biological Activity

Chemokine CX3CR1 (fractalkine receptor) antagonist. Inhibits fractalkine-induced ERK phosphorylation and decreases migration of breast cancer cells in vitro. Also inhibits circulating tumor cells from seeding into bone and reduces overall tumor burden in a breast cancer metastasis model.

Technical Data

M.Wt:
456.41
Formula:
C25H26ClN3O.HCl
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Drexel University.

Product Datasheets

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