JMS 17-2 hydrochloride

Tocris Bioscience | Catalog # 6378

CX3CR1 antagonist
Tocris Bioscience

Key Product Details

Description

CX3CR1 antagonist
View all Chemokine Receptor Antagonists »

Product Description

JMS 17-2 hydrochloride is a chemokine CX3CR1 (fractalkine receptor) antagonist. Inhibits fractalkine-induced ERK phosphorylation and decreases migration of breast cancer cells in vitro. Also inhibits circulating tumor cells from seeding into bone and reduces overall tumor burden in a breast cancer metastasis model.

Licensing Information

Sold under license from Drexel University.

Product Specifications for JMS 17-2 hydrochloride

Molecular Weight

456.41

Formula

C25H26ClN3O.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

5-[3-[4-(4-Chlorophenyl)-1-piperidinyl]propyl]pyrrolo[1,2-a]quinoxalin-4(5H)-one hydrochloride

CAS Number

2341841-07-2

SMILES

ClC1=CC=C(C2CCN(CC2)CCCN3C(C4=CC=CN4C5=CC=CC=C35)=O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.64 100
Ethanol 22.82 50

Preparing Stock Solutions for JMS 17-2 hydrochloride

The following data is based on the product molecular weight 456.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.19 mL 10.96 mL 21.91 mL
5 mM 0.44 mL 2.19 mL 4.38 mL
10 mM 0.22 mL 1.10 mL 2.19 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for JMS 17-2 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for JMS 17-2 hydrochloride

For research use only

Citations for JMS 17-2 hydrochloride

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