JNJ 0966

Key Product Details

Product Description

JNJ 0966 is a pro-MMP9 activation inhibitor (IC₅₀ = 440 nM). Inhibits the conversion of pro-MMP9 to active MMP9, without directly affecting MMP9 enzymatic activity. Exhibits selectivity for pro-MMP9 over pro-MMP1, 2 and 3. Inhibits cell invasion in in vitro assays. Reduces motor impairment in a mouse EAE model. Brain penetrant.

Product Specifications for JNJ 0966

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for JNJ 0966

The following data is based on the product molecular weight 360.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.55 mL	27.74 mL	55.49 mL
2.5 mM	1.11 mL	5.55 mL	11.10 mL
5 mM	0.55 mL	2.77 mL	5.55 mL
25 mM	0.11 mL	0.55 mL	1.11 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Scannevin Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation. J.Biol.Chem. 2017 PMID: 28860188

Product Documents for JNJ 0966