JNJ 0966

Catalog # Availability Size / Price Qty
6439/10
6439/50
Synthetic Metalloprotease Inhibitors Small Molecule
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Description: Pro-MMP9 activation inhibitor

Chemical Name: N-[2-[(2-Methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]acetamide

Purity: ≥98%

Product Details
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Biological Activity

Pro-MMP9 activation inhibitor (IC50 = 440 nM). Inhibits the conversion of pro-MMP9 to active MMP9, without directly affecting MMP9 enzymatic activity. Exhibits selectivity for pro-MMP9 over pro-MMP1, 2 and 3. Inhibits cell invasion in in vitro assays. Reduces motor impairment in a mouse EAE model. Brain penetrant.

Technical Data

M.Wt:
360.45
Formula:
C16H16N4O2S2
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
315705-75-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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