JNJ 10397049

Catalog # Availability Size / Price Qty
4317/10
4317/50
Cat.No. 4317 - JNJ 10397049 | C19H20Br2N2O3 | CAS No. 708275-58-5
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Description: Selective OX2 receptor antagonist

Chemical Name: N-(2,4-Dibromophenyl)-N'-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]-urea

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

Selective OX2 receptor antagonist (pIC50 = 7.4 for chimeric OX2 receptors; pKB values are 5.9 and 8.5 for OX1 and OX2 receptors respectively). Shows no significant activity in a panel of over 50 other neurotransmitters and neuropeptide receptors. Achieves high level of OX2 receptor occupancy in the rat brain; exhibits sleep-promoting effects in rats.

Technical Data

M.Wt:
484.18
Formula:
C19H20Br2N2O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
708275-58-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citation for JNJ 10397049

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