Chemical Name: N-(2,4-Dibromophenyl)-N'-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]-urea
Biological ActivitySelective OX2 receptor antagonist (pIC50 = 7.4 for chimeric OX2 receptors; pKB values are 5.9 and 8.5 for OX1 and OX2 receptors respectively). Shows no significant activity in a panel of over 50 other neurotransmitters and neuropeptide receptors. Achieves high level of OX2 receptor occupancy in the rat brain; exhibits sleep-promoting effects in rats.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat.
Dugovic et al.
Chimeric, mutant orexin receptors show key interactions between orexin receptors, peptides and antagonists.
Tran et al.
Functional magnetic resonance imaging reveals different neural substrates for the effects of orexin-1 and orexin-2 receptor antagonists.
Gozzi et al.
PLoS ONE, 2011;6:e16406
Citation for JNJ 10397049
The citations listed below are publications that use Tocris products. Selected citations for JNJ 10397049 include:
1 Citation: Showing 1 - 1
Promotion of Wakefulness and Energy Expenditure by Orexin-A in the Ventrolateral Preoptic Area.
Authors: Mavanji Et al.
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