JNJ 28871063 hydrochloride

   
Product Datasheet
Catalog Number:3352
Chemical Name:5E-4-Amino-6-(4-benzyloxy-3-chlorophenylamino)pyrimidine-5-carboxaldehyde N-(2-morpholin-4-ylethyl) oxime hydrochloride
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Biological Activity
Potent and selective ErbB receptor family inhibitor (IC50 values are 21, 22 and 38 nM for ErbB4, EGFR and ErbB2 respectively). Displays potent growth inhibition of human cancer cell lines overexpressing ErbB2 in vitro (IC50 = 60 - 168 nM) and inhibits growth of human tumor xenografts in vivo. Brain penetrant and orally active.
Technical Data
  • M.Wt:
    519.42
  • Formula:
    C24H27ClN6O3.HCl
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >97
  • Storage:
    Desiccate at +4°C
  • CAS No:
    944342-90-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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