JNJ 28871063 hydrochloride

Key Product Details

Product Description

JNJ 28871063 hydrochloride is a potent and selective ErbB receptor family inhibitor (IC₅₀ values are 21, 22 and 38 nM for ErbB4, EGFR and ErbB2 respectively). Displays potent growth inhibition of human cancer cell lines overexpressing ErbB2 in vitro (IC₅₀ = 60 - 168 nM) and inhibits growth of human tumor xenografts in vivo. Brain penetrant and orally active.

Product Specifications for JNJ 28871063 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for JNJ 28871063 hydrochloride

The following data is based on the product molecular weight 519.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.85 mL	19.25 mL	38.50 mL
2.5 mM	0.77 mL	3.85 mL	7.70 mL
5 mM	0.39 mL	1.93 mL	3.85 mL
25 mM	0.08 mL	0.39 mL	0.77 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Emanuel Cellular and in vivo activity of JNJ-28871063, a nonquinazoline pan-ErbB kinase inhibitor that crosses the blood-brain barrier and displays efficacy against intracranial tumors. Mol.Pharmacol. 2008 PMID: 17975007
• Guessous Signaling pathways in medulloblastoma. J.Cell.Phys. 2008 PMID: 18651559
• Contessa and Hamstra Revoking the privilege: targeting HER2 in the central nervous system. Mol.Pharmacol. 2008 PMID: 17981994

Product Documents for JNJ 28871063 hydrochloride