JNJ 28871063 hydrochloride

Discontinued Product

3352 has been discontinued.
View all EGF Receptor Inhibitors products.
JNJ 28871063 hydrochloride | CAS No. 944342-90-9 | EGF Receptor Inhibitors
1 Image
Description: Potent ErbB receptor family inhibitor

Chemical Name: 5E-4-Amino-6-(4-benzyloxy-3-chlorophenylamino)pyrimidine-5-carboxaldehyde N-(2-morpholin-4-ylethyl) oxime hydrochloride

Purity: ≥97%

Product Details

Biological Activity

JNJ 28871063 hydrochloride is a potent and selective ErbB receptor family inhibitor (IC50 values are 21, 22 and 38 nM for ErbB4, EGFR and ErbB2 respectively). Displays potent growth inhibition of human cancer cell lines overexpressing ErbB2 in vitro (IC50 = 60 - 168 nM) and inhibits growth of human tumor xenografts in vivo. Brain penetrant and orally active.

Technical Data

Soluble to 50 mM in DMSO
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Revoking the privilege: targeting HER2 in the central nervous system.
    Contessa and Hamstra
    Mol.Pharmacol., 2008;73:271
  2. Cellular and in vivo activity of JNJ-28871063, a nonquinazoline pan-ErbB kinase inhibitor that crosses the blood-brain barrier and displays efficacy against intracranial tumors.
    Emanuel et al.
    Mol.Pharmacol., 2008;73:338
  3. Signaling pathways in medulloblastoma.
    Guessous et al.
    J.Cell.Phys., 2008;217:577

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for JNJ 28871063 hydrochloride

There are currently no reviews for this product. Be the first to review JNJ 28871063 hydrochloride and earn rewards!

Have you used JNJ 28871063 hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.