JNJ 303

Catalog # Availability Size / Price Qty
JNJ 303 | CAS No. 878489-28-2 | Voltage-gated Potassium Channel Blockers
1 Image
Description: Potent and selective IKs blocker

Chemical Name: 2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[,7]dec-2-yl]-propanamide

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

JNJ 303 is a potent IKs blocker (IC50 = 64 nM). Displays no effects on other cardiac channels; IC50 values are 3.3, >10, 11.1 and 12.6 μM for INa, ICa, Ito and IKr currents respectively. Prolongs QT and causes unprovoked torsades de pointes (TdP).

Technical Data

Soluble to 25 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Janssen Pharmaceutica NV

Background References

  1. Blockade of the IKs potassium channel: an overlooked cardiovascular liability in drug safety screening?
    Towart et al.
    J.Pharm.Toxicol.Meth, 2009;60:1

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for JNJ 303

The citations listed below are publications that use Tocris products. Selected citations for JNJ 303 include:

1 Citation: Showing 1 - 1


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for JNJ 303

There are currently no reviews for this product. Be the first to review JNJ 303 and earn rewards!

Have you used JNJ 303?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.