= 64 nM). Displays no effects on other cardiac channels; IC50
values are 3.3, >10, 11.1 and 12.6 μ
M for INa
currents respectively. Prolongs QT and causes unprovoked torsades de pointes (TdP).
Soluble to 25 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold with the permission of Janssen Pharmaceutica NV
Blockade of the IKs potassium channel: an overlooked cardiovascular liability in drug safety screening?
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