JNJ 303

Catalog # Availability Size / Price Qty
3899/10
3899/50
Voltage-gated Potassium Channel Blockers Small Molecule
1 Image
Description: Potent and selective IKs blocker

Chemical Name: 2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[3.3.1.13,7]dec-2-yl]-propanamide

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Potent IKs blocker (IC50 = 64 nM). Displays no effects on other cardiac channels; IC50 values are 3.3, >10, 11.1 and 12.6 μM for INa, ICa, Ito and IKr currents respectively. Prolongs QT and causes unprovoked torsades de pointes (TdP).

Technical Data

M.Wt:
440.98
Formula:
C21H29ClN2O4S
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
878489-28-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Janssen Pharmaceutica NV

Background References

  1. Blockade of the IKs potassium channel: an overlooked cardiovascular liability in drug safety screening?
    Towart et al.
    J.Pharm.Toxicol.Meth, 2009;60:1

Product Datasheets

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Citation for JNJ 303

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