JNJ 303

Tocris Bioscience | Catalog # 3899

Potent and selective IKs blocker
Tocris Bioscience

Key Product Details

Description

Potent and selective IKs blocker
View all Voltage-gated Potassium Channel Blockers »

Product Description

JNJ 303 is a potent IKs blocker (IC50 = 64 nM). Displays no effects on other cardiac channels; IC50 values are 3.3, >10, 11.1 and 12.6 μM for INa, ICa, Ito and IKr currents respectively. Prolongs QT and causes unprovoked torsades de pointes (TdP).

Licensing Information

Sold with the permission of Janssen Pharmaceutica NV

Product Specifications for JNJ 303

Molecular Weight

440.98

Formula

C21H29ClN2O4S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[3.3.1.13,7]dec-2-yl]-propanamide

CAS Number

878489-28-2

PubChem ID

73016713

InChI Key

OSGIRCJRKSAODN-UHFFFAOYSA-N

SMILES

O=C(C(C)(C)OC4=CC=C(Cl)C=C4)NC2C1CC(CC2C3)CC3(NS(=O)(C)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.02 25

Preparing Stock Solutions for JNJ 303

The following data is based on the product molecular weight 440.98.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 9.07 mL 45.35 mL 90.71 mL
1.25 mM 1.81 mL 9.07 mL 18.14 mL
2.5 mM 0.91 mL 4.54 mL 9.07 mL
12.5 mM 0.18 mL 0.91 mL 1.81 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 20 publications citing the usage of this product.

  • Towart Blockade of the IKs potassium channel: an overlooked cardiovascular liability in drug safety screening? J.Pharm.Toxicol.Meth

Product Documents for JNJ 303

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for JNJ 303

For research use only

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