Chemical Name: 2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[220.127.116.11,7]dec-2-yl]-propanamide
Biological ActivityPotent IKs blocker (IC50 = 64 nM). Displays no effects on other cardiac channels; IC50 values are 3.3, >10, 11.1 and 12.6 μM for INa, ICa, Ito and IKr currents respectively. Prolongs QT and causes unprovoked torsades de pointes (TdP).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Blockade of the IKs potassium channel: an overlooked cardiovascular liability in drug safety screening?
Towart et al.
Citation for JNJ 303
The citations listed below are publications that use Tocris products. Selected citations for JNJ 303 include:
1 Citation: Showing 1 - 1
Evaluation of Optogenetic Electrophysiology Tools in Human Stem Cell-Derived Cardiomyocytes.
Authors: Bj?rk Et al.
Front Physiol 2017;8:884
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