Chemical Name: 2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[184.108.40.206,7]dec-2-yl]-propanamide
Biological ActivityJNJ 303 is a potent IKs blocker (IC50 = 64 nM). Displays no effects on other cardiac channels; IC50 values are 3.3, >10, 11.1 and 12.6 μM for INa, ICa, Ito and IKr currents respectively. Prolongs QT and causes unprovoked torsades de pointes (TdP).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Blockade of the IKs potassium channel: an overlooked cardiovascular liability in drug safety screening?
Towart et al.
Citation for JNJ 303
The citations listed below are publications that use Tocris products. Selected citations for JNJ 303 include:
1 Citation: Showing 1 - 1
Evaluation of Optogenetic Electrophysiology Tools in Human Stem Cell-Derived Cardiomyocytes.
Authors: Bj?rk Et al.
Front Physiol 2017;8:884
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