Chemical Name: 1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine
Biological ActivityJNJ 7777120 is a histamine H4 receptor antagonist; displays high affinity (Ki = 4.5 nM) and is >1000-fold selective for H4 over other histamine receptors.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties.
Strakhova et al.
The first potent and selective non-imidazole human histamine H4 receptor antagonists.
Jablanowski et al.
A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties.
Thurmond et al.
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