Catalog Number: 4021
Chemical Name: 1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine
Biological Activity
Histamine H4 receptor antagonist; displays high affinity (Ki = 4.5 nM) and is >1000-fold selective for H4 over other histamine receptors.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in 1eq. HCl and to 50 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Ortho-McNeil-Janssen Pharmaceuticals, Inc.
Background References
  1. The first potent and selective non-imidazole human histamine H4 receptor antagonists.
    Jablanowski et al.
    J.Med.Chem., 2003;46:3957
  2. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties.
    Thurmond et al.
    J.Pharmacol.Exp.Ther., 2004;309:404
  3. In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties.
    Strakhova et al.
    Br.J.Pharmacol., 2009;157:44
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