JNJ 7777120

Key Product Details

Product Description

JNJ 7777120 is a histamine H₄ receptor antagonist; displays high affinity (K_i = 4.5 nM) and is >1000-fold selective for H₄ over other histamine receptors.

Licensing Information

Sold with the permission of Ortho-McNeil-Janssen Pharmaceuticals, Inc.

Product Specifications for JNJ 7777120

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for JNJ 7777120

The following data is based on the product molecular weight 277.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.60 mL	18.00 mL	36.00 mL
5 mM	0.72 mL	3.60 mL	7.20 mL
10 mM	0.36 mL	1.80 mL	3.60 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 23 publications citing the usage of this product.

• Thurmond A potent and selective histamine H₄ receptor antagonist with anti-inflammatory properties. J.Pharmacol.Exp.Ther. 2004 PMID: 14722321
• Strakhova In vitro and in vivo characterization of A-940894: a potent histamine H₄ receptor antagonist with anti-inflammatory properties. Br.J.Pharmacol. 2009 PMID: 19413570
• Jablanowski The first potent and selective non-imidazole human histamine H₄ receptor antagonists. J.Med.Chem. 2003 PMID: 12954048

Product Documents for JNJ 7777120