Chemical Name: 3-Bromo-4-[2-fluoro-4-[[4-oxo-2-[[2-(pyridin-2-yl)ethyl]amino]-1,3-thiazol-5-(4H)ylidene]methyl]phenoxy]benzonitrile
Biological ActivityDGAT2 inhibitor (IC50 = 140 nM). Exhibits >70-fold selectivity for DGAT2 over DGAT1 and MGAT2.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2
Qi et al.
J.Lipid Res., 2012;53:1106
Diacylglycerol acyltransferase 2 links glucose utilization to fatty acid oxidation in the brown adipocytes.
Irshad et al.
J.Lipid Res., 2017;58:15
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