Catalog Number: 5853
Chemical Name: 3-Bromo-4-[2-fluoro-4-[[4-oxo-2-[[2-(pyridin-2-yl)ethyl]amino]-1,3-thiazol-5-(4H)ylidene]methyl]phenoxy]benzonitrile
Biological Activity
DGAT2 inhibitor (IC50 = 140 nM). Exhibits >70-fold selectivity for DGAT2 over DGAT1 and MGAT2.
Technical Data
  • M.Wt:
    523.38
  • Formula:
    C24H16BrFN4O2S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Store at +4°C
  • CAS No:
    1962931-71-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2
    Qi et al.
    J.Lipid Res., 2012;53:1106
  2. Diacylglycerol acyltransferase 2 links glucose utilization to fatty acid oxidation in the brown adipocytes.
    Irshad et al.
    J.Lipid Res., 2017;58:15

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