(+)-JQ1 carboxylic acid

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(+)-JQ1 carboxylic acid | CAS No. 202592-23-2 | Degrader Building Blocks
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Description: Carboxylic acid-functionalized BET bromodomain inhibitor; target ligand for PROTACs

Chemical Name: (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid

Purity: ≥98%

Product Details

Biological Activity

(+)-JQ1 carboxylic acid is a BET bromodomain inhibitor (+)-JQ1 (Cat. No. 4499) with a carboxylic acid functional group for conjugation reactions. Can be used as a precursor to PROTAC® Degraders that targets BET bromodomains after conjugation to a linker and E3 ligase ligand.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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