(+)-JQ1 carboxylic acid
Chemical Name: (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid
Biological ActivityBET bromodomain inhibitor (+)-JQ1 (Cat. No. 4499) with a carboxylic acid functional group for conjugation reactions. Can be used as a precursor to PROTACs that target BET bromodomains after conjugation to a linker and E3 ligase ligand.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Selective small molecule induced degradation of the BET bromodomain protein BRD4.
Zengerle et al.
Structural basis of PROTAC cooperative recognition for selective protein degradation.
Gadd et al.
DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation.
Winter et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for (+)-JQ1 carboxylic acid
There are currently no reviews for this product. Be the first to review (+)-JQ1 carboxylic acid and earn rewards!
Have you used (+)-JQ1 carboxylic acid?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image