JQ1-FITC

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JQ1-FITC | Fluorescent Probes
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Description: Fluorescent BET bromodomain probe; suitable for use in TR-FRET

Chemical Name: (S)-5-(3-(1-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-2-oxo-7,10,13-trioxa-3-azahexadecan-16-yl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid trifluoroacetate

Purity: ≥95%

Product Details
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Biological Activity

JQ1-FITC is a fluorescent BET bromodomain probe. It binds with high affinity to BRD4(BD1) and BRD4(BD2) (KD,app = 6.5 nM and 5.8 nM, respectively). Suitable for use in TR-FRET. Excitation and emission maxima (λ) are 495 nm and 525 nm, respectively.

Optical Data for JQ1-FITC

JQ1-FITC Dye Spectra
Emission Color Green
λabs 495 nm
λem 525 nm
Extinction Coefficient (ε) 7500 M-1cm-1
Quantum Yield (φ) 0.92
Closest Laser line 488 nm
Application TR-FRET, Fluorescence polarization assays
Alternative For FITC

Plan Your Experiments

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Technical Data

M.Wt:
1106.58
Formula:
C50H50ClN7O9S2.CF3CO2H
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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