JT010

Catalog # Availability Size / Price Qty
6269/5
6269/25
Cat.No. 6269 - JT010 | C16H19ClN2O3S | CAS No. 917562-33-5
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Description: Potent and selective TRPA1 channel activator

Chemical Name: 2-Chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)acetamide

Purity: ≥98%

Product Details
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Biological Activity

Potent and selective TRPA1 channel activator (EC50 = 65 nM); activates the TRPA1 channel by covalently and site-selectively binding to Cys621. Exhibits selectivity for TRPA1 over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC50 values are >1 μM).

Technical Data

M.Wt:
354.85
Formula:
C16H19ClN2O3S
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
917562-33-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. A Potent and Site-Selective Agonist of TRPA1.
    Takaya J, Mio K, Shiraishi T et al.
    J. Am. Chem. Soc.

Product Datasheets

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