JW 67

Catalog # Availability Size / Price Qty
4651/10
4651/50
Cat.No. 4651 - JW 67 | C21H18N2O6 | CAS No. 442644-28-2
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Description: Wnt pathway inhibitor; induces degradation of active β-catenin

Chemical Name: Trispiro[3H-indole-3,2'-[1,3]dioxane-2'',3'''-[3H]indole]-2,2'''(1H,1'''H)-dione

Purity: ≥97%

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Biological Activity

Inhibitor of canonical Wnt pathway signaling (IC50 = 1.17 μM); targets the β-catenin destruction complex (GSK-3β/AXIN/APC) to induce β-catenin degradation. Selective for the canonical Wnt pathway over the Sonic hedgehog (Shh) and NF-κB pathways. Blocks G1/S cell cycle progression in colorectal cancer (CRC) cell lines (GI50 = 7.8 μM).

Technical Data

M.Wt:
394.38
Formula:
C21H18N2O6
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at +4°C
CAS No:
442644-28-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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