Inhibitor of canonical Wnt pathway signaling (IC50
= 1.17 μ
M); targets the β
-catenin destruction complex (GSK-3β
/AXIN/APC) to induce β
-catenin degradation. Selective for the canonical Wnt pathway over the Sonic hedgehog (Shh) and NF-κ
B pathways. Blocks G1
/S cell cycle progression in colorectal cancer (CRC) cell lines (GI50
= 7.8 μ
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
[1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding.
Shultz et al.
Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth.
Waaler et al.
Cancer Res., 2011;71:197