Chemical Name: 4-[4-(4-Methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-pyridine
Biological ActivityJW 74 is an inhibitor of canonical Wnt signaling (IC50 = 790 nM). Targets the β-catenin destruction complex (GSK-3�/AXIN/APC). Increases AXIN2 and decreases active β-catenin levels in colorectal cancer (CRC) cells. Also arrests cell cycle in G1 and inhibits proliferation of CRC cells in vitro. Inhibits tumor growth and formation in mouse models.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth.
Waaler et al.
Cancer Res., 2011;71:197
Citation for JW 74
The citations listed below are publications that use Tocris products. Selected citations for JW 74 include:
1 Citation: Showing 1 - 1
Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis.
Cell Discov 2018;4:21
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