Catalog Number: 1341
Chemical Name: (2-Methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone
Biological Activity
Selective CB2 agonist (Ki values are 13.8 and 383 nM as measured at human cloned CB2 and CB1 receptors expressed in CHO cells).
Technical Data
  • M.Wt:
    327.43
  • Formula:
    C23H21NO
  • Solubility:
    Soluble to 10 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    155471-08-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacology of cannabinoid receptor ligands.
    Pertwee
    Curr.Med.Chem., 1999;6:635
  2. The third transmembrane helix of the cannabinoid receptor plays a role in the selectivity of aminoalkylindoles for CB2, peripheral cannabinoid receptor.
    Chin et al.
    J.Pharmacol.Exp.Ther., 1999;291:837
  3. Evidence for the presence of CB2-like receptor on peripheral nerve terminals.
    Griffin et al.
    Eur.J.Pharmacol., 1997;339:53
Citations:

The citations listed below are publications that use Tocris products. Selected citations for JWH 015 include:

8 Citations: Showing 1 - 8
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  1. Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells.
    Authors: Jiang Et al.
    PLoS One ;2:e641
  2. Alcohol and Cannabinoids Differentially Affect HIV Infection and Function of Human Monocyte-Derived Dendritic Cells (MDDC).
    Authors: Agudelo Et al.
    Front Microbiol 2016;6:1452
  3. Anti-Obesity Effect of the CB2 Receptor Agonist JWH-015 in Diet-Induced Obese Mice.
    Authors: Verty Et al.
    PLoS One 2015;10:e0140592
  4. Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis.
    Authors: Preet Et al.
    Cancer Prev Res (Phila) 2011;4:65
  5. Endocannabinoid signal in the gut controls dietary fat intake.
    Authors: DiPatrizio Et al.
    Proc Natl Acad Sci U S A 2011;108:12904
  6. Characterizing cannabinoid CB2 receptor ligands using DiscoveRx PathHunter β-arrestin assay.
    Authors: McGuinness Et al.
    Mol Pharmacol 2009;14:49
  7. Cannabinoid receptor type 2 agonists induce transcription of the mu-opioid receptor gene in Jurkat T cells.
    Authors: Börner Et al.
    Mol Cell Neurosci 2006;69:1486
  8. Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation.
    Authors: Ehrhart Et al.
    J Neuroinflammation 2005;2:29

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