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JWH 015

Catalog #: 1341
21 Citations Datasheet / COA / SDS

Discontinued Product

1341 has been discontinued.
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JWH 015 | CAS No. 155471-08-2 | Cannabinoid R2/CB2 Agonists
1 Image
Description: Selective CB2 agonist

Chemical Name: (2-Methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone

Purity: ≥99%

Product Details
Citations (21)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Selective CB2 agonist (Ki values are 13.8 and 383 nM as measured at human cloned CB2 and CB1 receptors expressed in CHO cells).

Technical Data

M.Wt:
327.43
Formula:
C23H21NO
Solubility:
Soluble to 10 mM in DMSO and to 25 mM in ethanol
Purity:
≥99%
Storage:
Desiccate at -20°C
CAS No:
155471-08-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for JWH 015

The citations listed below are publications that use Tocris products. Selected citations for JWH 015 include:

21 Citations: Showing 1 - 10

  1. Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells.
    Authors: Jiang Et al.
    PLoS One  ;2:e641
  2. Antiallodynic Effects of Cannabinoid Receptor 2 (CB2R) Agonists on Retrovirus Infection-Induced Neuropathic Pain.
    Authors: Sheng Et al.
    Pain Res Manag  2019;2019:1260353
  3. Cannabinoid Receptor 2 Agonist JWH-015 Inhibits Interleukin-1β-Induced Inflammation in Rheumatoid Arthritis Synovial Fibroblasts and in Adjuvant Induced Arthritis Rat via Glucocorticoid Receptor.
    Authors: Fechtner Et al.
    Front Immunol  2019;10:1027
  4. The Endocannabinoid/Cannabinoid Receptor 2 System Protects Against Cisplatin-Induced Hearing Loss.
    Authors: Ghosh Et al.
    Front Cell Neurosci  2018;12:271
  5. Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent.
    Authors: Hanlon Et al.
    Breast Cancer (Dove Med Press)  2016;8:59
  6. Alcohol and Cannabinoids Differentially Affect HIV Infection and Function of Human Monocyte-Derived Dendritic Cells (MDDC).
    Authors: Agudelo Et al.
    Front Microbiol  2016;6:1452
  7. Anti-Obesity Effect of the CB2 Receptor Agonist JWH-015 in Diet-Induced Obese Mice.
    Authors: Verty Et al.
    PLoS One  2015;10:e0140592
  8. Cannabinoids inhibit T-cells via cannabinoid receptor 2 in an in vitro assay for graft rejection, the mixed lymphocyte reaction.
    Authors: Robinson Et al.
    J Neuroimmune Pharmacol  2013;8:1239
  9. Spinal cannabinoid receptor type 2 agonist reduces mechanical allodynia and induces mitogen-activated protein kinase phosphatases in a rat model of neuropathic pain.
    Authors: Landry Et al.
    J Pain  2012;13:836
  10. The antinociceptive effects of JWH-015 in chronic inflammatory pain are produced by nitric oxide-cGMP-PKG-KATP pathway activation mediated by opioids.
    Authors: Negrete Et al.
    PLoS One  2011;6:e26688
  11. Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis.
    Authors: Preet Et al.
    Cancer Prev Res (Phila)  2011;4:65
  12. Endocannabinoid signal in the gut controls dietary fat intake.
    Authors: DiPatrizio Et al.
    Proc Natl Acad Sci U S A  2011;108:12904
  13. The role of nitric oxide in the local antiallodynic and antihyperalgesic effects and expression of delta-opioid and cannabinoid-2 receptors during neuropathic pain in mice.
    Authors: Hervera Et al.
    J Pharmacol Exp Ther  2010;334:887
  14. WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.
    Authors: Price Et al.
    Eur J Neurosci  2009;29:2177
  15. Characterizing cannabinoid CB2 receptor ligands using DiscoveRx PathHunter β-arrestin assay.
    Authors: McGuinness Et al.
    Mol Pharmacol  2009;14:49
  16. Cannabinoid receptor type 2 agonists induce transcription of the mu-opioid receptor gene in Jurkat T cells.
    Authors: Börner Et al.
    Mol Cell Neurosci  2006;69:1486
  17. Anti-inflammatory potential of CB1-mediated cAMP elevation in mast cells.
    Authors: Small-Howard Et al.
    Biochem J  2005;388:465
  18. Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation.
    Authors: Ehrhart Et al.
    J Neuroinflammation  2005;2:29
  19. Endocannabinoids protect the rat isolated heart against ischaemia.
    Authors: Lépicier Et al.
    Br J Pharmacol  2003;139:805
  20. Evidence of a novel site mediating anandamide-induced negative inotropic and coronary vasodilatator responses in rat isolated hearts.
    Authors: Ford Et al.
    Br J Pharmacol  2002;135:1191
  21. Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease.
    Authors: McKallip Et al.
    Blood  2002;100:627

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