JWH 015

  ( 15 citations )    
Product Datasheet
Catalog Number:1341
Chemical Name:(2-Methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone
Product Details
Citations (15)
Supplemental Products
Reviews
Biological Activity
Selective CB2 agonist (Ki values are 13.8 and 383 nM as measured at human cloned CB2 and CB1 receptors expressed in CHO cells).
Technical Data
  • M.Wt:
    327.43
  • Formula:
    C23H21NO
  • Solubility:
    Soluble to 10 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >99
  • Storage:
    Desiccate at -20°C
  • CAS No:
    155471-08-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for JWH 015 include:

15 Citations: Showing 1 - 10
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  1. Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells.
    Authors: Jiang Et al.
    PLoS One  ;2:e641
  2. Alcohol and Cannabinoids Differentially Affect HIV Infection and Function of Human Monocyte-Derived Dendritic Cells (MDDC).
    Authors: Agudelo Et al.
    Front Microbiol  2016;6:1452
  3. Anti-Obesity Effect of the CB2 Receptor Agonist JWH-015 in Diet-Induced Obese Mice.
    Authors: Verty Et al.
    PLoS One  2015;10:e0140592
  4. Cannabinoids inhibit T-cells via cannabinoid receptor 2 in an in vitro assay for graft rejection, the mixed lymphocyte reaction.
    Authors: Robinson Et al.
    J Neuroimmune Pharmacol  2013;8:1239
  5. The antinociceptive effects of JWH-015 in chronic inflammatory pain are produced by nitric oxide-cGMP-PKG-KATP pathway activation mediated by opioids.
    Authors: Negrete Et al.
    PLoS One  2011;6:e26688
  6. Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis.
    Authors: Preet Et al.
    Cancer Prev Res (Phila)  2011;4:65
  7. Endocannabinoid signal in the gut controls dietary fat intake.
    Authors: DiPatrizio Et al.
    Proc Natl Acad Sci U S A  2011;108:12904
  8. The role of nitric oxide in the local antiallodynic and antihyperalgesic effects and expression of delta-opioid and cannabinoid-2 receptors during neuropathic pain in mice.
    Authors: Hervera Et al.
    J Pharmacol Exp Ther  2010;334:887
  9. WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.
    Authors: Price Et al.
    Eur J Neurosci  2009;29:2177
  10. Characterizing cannabinoid CB2 receptor ligands using DiscoveRx PathHunter β-arrestin assay.
    Authors: McGuinness Et al.
    Mol Pharmacol  2009;14:49
  11. Cannabinoid receptor type 2 agonists induce transcription of the mu-opioid receptor gene in Jurkat T cells.
    Authors: Börner Et al.
    Mol Cell Neurosci  2006;69:1486
  12. Anti-inflammatory potential of CB1-mediated cAMP elevation in mast cells.
    Authors: Small-Howard Et al.
    Biochem J  2005;388:465
  13. Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation.
    Authors: Ehrhart Et al.
    J Neuroinflammation  2005;2:29
  14. Evidence of a novel site mediating anandamide-induced negative inotropic and coronary vasodilatator responses in rat isolated hearts.
    Authors: Ford Et al.
    Br J Pharmacol  2002;135:1191
  15. Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease.
    Authors: McKallip Et al.
    Blood  2002;100:627
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