Chemical Name: Bis(morpholinothiocarbonyl) disulfide
Biological ActivityPotent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor (IC50 values are 49, 101 and 313 nM for PDK1, PDK2 and PDK3, respectively). Exhibits selectivity for PDK1/2/3 over PDK4 and a panel of 323 other kinases. Suppresses A549 lung cancer cell proliferation in vitro. Reduces tumor volume of A549 xenografts in mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
JX06 selectively inhibits pyruvate dehydrogenase kinase PDK1 by a covalent cysteine modification.
Sun et al.
Cancer Res., 2015;75:4923
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