JX 06

Catalog # Availability Size / Price Qty
5845/10
5845/50
Cat.No. 5845 - JX 06 | C10H16N2O2S4 | CAS No. 729-46-4
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Description: Potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor

Chemical Name: Bis(morpholinothiocarbonyl) disulfide

Purity: ≥98%

Product Details
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Biological Activity

Potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor (IC50 values are 49, 101 and 313 nM for PDK1, PDK2 and PDK3, respectively). Exhibits selectivity for PDK1/2/3 over PDK4 and a panel of 323 other kinases. Suppresses A549 lung cancer cell proliferation in vitro. Reduces tumor volume of A549 xenografts in mice.

Technical Data

M.Wt:
324.51
Formula:
C10H16N2O2S4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
729-46-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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