Chemical Name: Bis(morpholinothiocarbonyl) disulfide
Biological ActivityJX 06 is a potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor (IC50 values are 49, 101 and 313 nM for PDK1, PDK2 and PDK3, respectively). Exhibits selectivity for PDK1/2/3 over PDK4 and a panel of 323 other kinases. Suppresses A549 lung cancer cell proliferation in vitro. Reduces tumor volume of A549 xenografts in mice.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
JX06 selectively inhibits pyruvate dehydrogenase kinase PDK1 by a covalent cysteine modification.
Sun et al.
Cancer Res., 2015;75:4923
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