Potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor (IC50
values are 28, 49 and 313 nM for PDK2, PDK1 and PDK3, respectively). Exhibits selectivity for PDK1/2/3 over PDK4 and a panel of 323 other kinases. Suppresses A549 lung cancer cell proliferation in vitro
. Reduces tumor volume of A549 xenografts in mice.
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All Tocris products are intended for laboratory research use only.
JX06 selectively inhibits pyruvate dehydrogenase kinase PDK1 by a covalent cysteine modification.
Sun et al.
Cancer Res., 2015;75:4923