K 02288

Key Product Details

Product Description

K 02288 is a potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC₅₀ values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively). Reduces BMP4-induced Smad1/5/8 phosphorylation in vitro (IC₅₀ = 100 nM) and induces dorsalization of zebrafish embryos.

Product Specifications for K 02288

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for K 02288

The following data is based on the product molecular weight 352.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.84 mL	14.19 mL	28.38 mL
5 mM	0.57 mL	2.84 mL	5.68 mL
10 mM	0.28 mL	1.42 mL	2.84 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

• Mohedas Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chem.Biol. 2013 PMID: 23547776
• Sanvitale A new class of small molecule inhibitor of BMP signaling. PLoS ONE 2013 PMID: 23646137

Product Documents for K 02288