Chemical Name: 3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol
Biological ActivityPotent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC50 values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively). Reduces BMP4-induced Smad1/5/8 phosphorylation in vitro (IC50 = 100 nM) and induces dorsalization of zebrafish embryos.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Development of an ALK2-biased BMP type I receptor kinase inhibitor.
Mohedas et al.
ACS Chem.Biol., 2013;8:1291
A new class of small molecule inhibitor of BMP signaling.
Sanvitale et al.
PLoS ONE, 2013;8:62721
Citation for K 02288
The citations listed below are publications that use Tocris products. Selected citations for K 02288 include:
1 Citation: Showing 1 - 1
SMAD signaling and redox imbalance cooperate to induce prostate cancer cell dormancy.
Authors: Bui Et al.
Cell Cycle 2015;14:1218
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for K 02288
There are currently no reviews for this product. Be the first to review K 02288 and earn rewards!
Have you used K 02288?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image