K 02288

  ( 1 citations )    
Product Datasheet
Catalog Number:4986
Alternate Names:K 02288a
Chemical Name:3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol
Product Details
Citations (1)
Supplemental Products
Reviews
Biological Activity
Potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC50 values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively). Reduces BMP4-induced Smad1/5/8 phosphorylation in vitro (IC50 = 100 nM) and induces dorsalization of zebrafish embryos.
Technical Data
  • M.Wt:
    352.38
  • Formula:
    C20H20N2O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    1431985-92-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for K 02288 include:

1 Citations: Showing 1 - 1

  1. SMAD signaling and redox imbalance cooperate to induce prostate cancer cell dormancy.
    Authors: Bui Et al.
    Cell Cycle  2015;14:1218

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