Potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC50
values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively). Reduces BMP4-induced Smad1/5/8 phosphorylation in vitro
= 100 nM) and induces dorsalization of zebrafish embryos.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
A new class of small molecule inhibitor of BMP signaling.
Sanvitale et al.
PLoS ONE, 2013;8:62721
Development of an ALK2-biased BMP type I receptor kinase inhibitor.
Mohedas et al.
ACS Chem.Biol., 2013;8:1291