Catalog Number: 4986
Alternate Names: K 02288a
Chemical Name: 3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol
Biological Activity
Potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC50 values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively). Reduces BMP4-induced Smad1/5/8 phosphorylation in vitro (IC50 = 100 nM) and induces dorsalization of zebrafish embryos.
Technical Data
  • M.Wt:
    352.38
  • Formula:
    C20H20N2O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    1431985-92-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A new class of small molecule inhibitor of BMP signaling.
    Sanvitale et al.
    PLoS ONE, 2013;8:62721
  2. Development of an ALK2-biased BMP type I receptor kinase inhibitor.
    Mohedas et al.
    ACS Chem.Biol., 2013;8:1291

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