Chemical Name: 3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol
Biological ActivityPotent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC50 values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively). Reduces BMP4-induced Smad1/5/8 phosphorylation in vitro (IC50 = 100 nM) and induces dorsalization of zebrafish embryos.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Development of an ALK2-biased BMP type I receptor kinase inhibitor.
Mohedas et al.
ACS Chem.Biol., 2013;8:1291
A new class of small molecule inhibitor of BMP signaling.
Sanvitale et al.
PLoS ONE, 2013;8:62721
Citation for K 02288
The citations listed below are publications that use Tocris products. Selected citations for K 02288 include:
1 Citation: Showing 1 - 1
SMAD signaling and redox imbalance cooperate to induce prostate cancer cell dormancy.
Authors: Bui Et al.
Cell Cycle 2015;14:1218
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