Selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor (IC50
= 1.3 μ
M). Induces mitotic arrest, caspase-3 activation and cell growth inhibition in HCT116 cells. Displays no effect on microtubule dynamics. Preferentially induces mitotic arrest in cancer cells.
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K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells.
Nakai et al.
Cancer Res., 2009;69:3901