K-(D-1-Nal)-FwLL-NH2
Discontinued Product
5830 has been discontinued.
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Description: High affinity and potent ghrelin receptor inverse agonist
Biological Activity
K-(D-1-Nal)-FwLL-NH2 is a high affinity and potent ghrelin receptor inverse agonist (Ki values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively). Blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways.Technical Data
M.Wt:
902.13
Formula:
C51H67N9O6
Sequence:
KXFWLL
(Modifications: X=D-1-Nal,Trp-4 = D-Trp, Leu-6 = C-terminal amide)
Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
1394288-22-2
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor.
Els et al.
J.Med.Chem., 2012;55:7437 -
Agonism, antagonism, and inverse agonism bias at the ghrelin receptor signaling.
M'Kadmi et al.
J.Biol.Chem., 2015;290:27021
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