K-(D-1-Nal)-FwLL-NH₂

Name: K-( D -1-Nal)-FwLL-NH 2
Brand: Tocris Bioscience
SKU: 5830

Tocris Bioscience | Catalog # 5830

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Product Documents

High affinity and potent ghrelin receptor inverse agonist

Discontinued Product

5830 has been discontinued. View all Additional Ghrelin Receptor Peptides products.

Technical Data
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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

High affinity and potent ghrelin receptor inverse agonist

View all Additional Ghrelin Receptor Peptides »

Product Description

K-(D-1-Nal)-FwLL-NH₂ is a high affinity and potent ghrelin receptor inverse agonist (K_i values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively). Blocks ghrelin receptor-mediated G_q- and G₁₃-dependent signaling pathways.

Product Specifications for K-(D-1-Nal)-FwLL-NH₂

Molecular Weight

902.13

Formula

C₅₁H₆₇N₉O₆

Storage

Store at -20°C

CAS Number

1394288-22-2

PubChem ID

71453489

InChI Key

NCMQVOQOKBIHPA-MHRDGXECSA-N

SMILES

[H]N[C@@H](CCCCN)C(=O)N[C@H](CC1=CC=CC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

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Background References

References are publications that support the biological activity of the product.

M'Kadmi Agonism, antagonism, and inverse agonism bias at the ghrelin receptor signaling. J.Biol.Chem. 2015 PMID: 26363071
Els An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor. J.Med.Chem. 2012 PMID: 22920150

Product Documents for K-(D-1-Nal)-FwLL-NH₂

Certificate of Analysis

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Product Specific Notices for K-(D-1-Nal)-FwLL-NH₂

For research use only

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